Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK12-MAPK Signaling Pathway in Diabetic Nephropathy
Joint Authors
Zhang, Luwei
Zhang, Jinhang
Liu, Xinnong
Liu, Shengli
Tian, Jun
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
To reveal the expression and possible role of tribbles homolog 3 (TRB3) in the incidence of type 2 diabetic nephropathy, we used immunohistochemistry, real-time quantitative PCR, western blot analysis, and enzyme-linked immunosorbent assay (ELISA) to study the expression of TRB3, extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase (ERK1/2 MAPK), transforming growth factor β1 (TGF-β1), and collagen type IV in kidneys of db/db diabetic mice and in murine renal mesangial cells stimulated with high glucose.
The expression of TRB3, TGF-β1, and collagen type IV was increased in kidneys of db/db diabetic mice.
TGF-β1 and collagen type IV regulated by high glucose through ERK1/2 MAPK were downregulated by silencing TRB3 in renal mesangial cells.
TRB3 may be involved in diabetic nephropathy by regulating the fibrosis cytokine TGF-β1 and collagen type IV through the ERK1/2 MAPK signaling pathway.
American Psychological Association (APA)
Zhang, Luwei& Zhang, Jinhang& Liu, Xinnong& Liu, Shengli& Tian, Jun. 2014. Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK12-MAPK Signaling Pathway in Diabetic Nephropathy. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040799
Modern Language Association (MLA)
Zhang, Luwei…[et al.]. Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK12-MAPK Signaling Pathway in Diabetic Nephropathy. Journal of Immunology Research No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1040799
American Medical Association (AMA)
Zhang, Luwei& Zhang, Jinhang& Liu, Xinnong& Liu, Shengli& Tian, Jun. Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK12-MAPK Signaling Pathway in Diabetic Nephropathy. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1040799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040799