Disruption of the Suprachiasmatic Nucleus Blunts a Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice
Joint Authors
Nakamura, Yuki
Ishimaru, Kayoko
Tahara, Yu
Shibata, Shigenobu
Nakao, Atsuhito
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Anaphylaxis is a severe systemic allergic reaction which is rapid in onset and potentially fatal, caused by excessive release of mediators including histamine and cytokines/chemokines from mast cells and basophils upon allergen/IgE stimulation.
Increased prevalence of anaphylaxis in industrialized countries requires urgent needs for better understanding of anaphylaxis.
However, the pathophysiology of the disease is not fully understood.
Here we report that the circadian clock may be an important regulator of anaphylaxis.
In mammals, the central clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus synchronizes and entrains peripheral circadian clock present in virtually all cell types via neural and endocrine pathways, thereby driving the daily rhythms in behavior and physiology.
We found that mechanical disruption of the SCN resulted in the absence of a time of day-dependent variation in passive systemic anaphylactic (PSA) reaction in mice, associated with loss of daily variations in serum histamine, MCP-1 (CCL2), and IL-6 levels.
These results suggest that the central SCN clock controls the time of day-dependent variation in IgE-mediated systemic anaphylactic reaction, which may provide a novel insight into the pathophysiology of anaphylaxis.
American Psychological Association (APA)
Nakamura, Yuki& Ishimaru, Kayoko& Tahara, Yu& Shibata, Shigenobu& Nakao, Atsuhito. 2014. Disruption of the Suprachiasmatic Nucleus Blunts a Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040875
Modern Language Association (MLA)
Nakamura, Yuki…[et al.]. Disruption of the Suprachiasmatic Nucleus Blunts a Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice. Journal of Immunology Research No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1040875
American Medical Association (AMA)
Nakamura, Yuki& Ishimaru, Kayoko& Tahara, Yu& Shibata, Shigenobu& Nakao, Atsuhito. Disruption of the Suprachiasmatic Nucleus Blunts a Time of Day-Dependent Variation in Systemic Anaphylactic Reaction in Mice. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1040875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040875