Mechanisms of Innate Lymphoid Cell and Natural Killer T Cell Activation during Mucosal Inflammation
Joint Authors
Nau, David
Altmayer, Nora
Mattner, Jochen
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Mucosal surfaces in the airways and the gastrointestinal tract are critical for the interactions of the host with its environment.
Due to their abundance at mucosal tissue sites and their powerful immunomodulatory capacities, the role of innate lymphoid cells (ILCs) and natural killer T (NKT) cells in the maintenance of mucosal tolerance has recently moved into the focus of attention.
While NKT cells as well as ILCs utilize distinct transcription factors for their development and lineage diversification, both cell populations can be further divided into three polarized subpopulations reflecting the distinction into Th1, Th2, and Th17 cells in the adaptive immune system.
While bystander activation through cytokines mediates the induction of ILC and NKT cell responses, NKT cells become activated also through the engagement of their canonical T cell receptors (TCRs) by (glyco)lipid antigens (cognate recognition) presented by the atypical MHC I like molecule CD1d on antigen presenting cells (APCs).
As both innate lymphocyte populations influence inflammatory responses due to the explosive release of copious amounts of different cytokines, they might represent interesting targets for clinical intervention.
Thus, we will provide an outlook on pathways that might be interesting to evaluate in this context.
American Psychological Association (APA)
Nau, David& Altmayer, Nora& Mattner, Jochen. 2014. Mechanisms of Innate Lymphoid Cell and Natural Killer T Cell Activation during Mucosal Inflammation. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040891
Modern Language Association (MLA)
Nau, David…[et al.]. Mechanisms of Innate Lymphoid Cell and Natural Killer T Cell Activation during Mucosal Inflammation. Journal of Immunology Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1040891
American Medical Association (AMA)
Nau, David& Altmayer, Nora& Mattner, Jochen. Mechanisms of Innate Lymphoid Cell and Natural Killer T Cell Activation during Mucosal Inflammation. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1040891
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040891