Temporal Regulation of Cytokines by the Circadian Clock
Author
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-06
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Several parameters of the immune system exhibit oscillations with a period of approximately 24 hours that refers to “circadian rhythms.” Such daily variations in host immune system status might evolve to maximize immune reactions at times when encounters with pathogens are most likely to occur.
However, the mechanisms behind circadian immunity have not been fully understood.
Recent studies reveal that the internal time keeping system “circadian clock” plays a key role in driving the daily rhythms evident in the immune system.
Importantly, several studies unveil molecular mechanisms of how certain clock proteins (e.g., BMAL1 and CLOCK) temporally regulate expression of cytokines.
Since cytokines are crucial mediators for shaping immune responses, this review mainly summarizes the new knowledge that highlights an emerging role of the circadian clock as a novel regulator of cytokines.
A greater understanding of circadian regulation of cytokines will be important to exploit new strategies to protect host against infection by efficient cytokine induction or to treat autoimmunity and allergy by ameliorating excessive activity of cytokines.
American Psychological Association (APA)
Nakao, Atsuhito. 2014. Temporal Regulation of Cytokines by the Circadian Clock. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1040922
Modern Language Association (MLA)
Nakao, Atsuhito. Temporal Regulation of Cytokines by the Circadian Clock. Journal of Immunology Research No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-1040922
American Medical Association (AMA)
Nakao, Atsuhito. Temporal Regulation of Cytokines by the Circadian Clock. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-1040922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040922