Immunopathogenesis of Ocular Behçet’s Disease
Joint Authors
Yu, Hyeong Gon
Park, Un Chul
Kim, Tae Wan
Source
Journal of Immunology Research
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-01
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Behçet’s disease (BD) is a chronic recurrent systemic inflammatory disorder of unknown etiology characterized by oral and genital ulcerations, skin lesions, and uveitis.
The ocular involvement of BD, or Behçet’s uveitis (BU), is characterized by panuveitis or posterior uveitis with occlusive retinal vasculitis and tends to be more recurrent and sight threatening than other endogenous autoimmune uveitides, despite aggressive immunosuppression.
Although pathogenesis of BD is unclear, researches have revealed that immunological aberrations may be the cornerstone of BD development.
General hypothesis of BD pathogenesis is that inflammatory response is initiated by infectious agents or autoantigens in patients with predisposing genetic factors and perpetuated by both innate and acquired immunity.
In addition, a network of immune mediators plays a substantial role in the inflammatory cascade.
Recently, we found that the immunopathogenesis of BU is distinct from other autoimmune uveitides regarding intraocular effector cell profiles, maturation markers of dendritic cells, and the cytokine/chemokine environment.
In addition, accumulating evidence indicates the involvement of Th17 cells in BD and BU.
Recent studies on genetics and biologics therapies in refractory BU also support the immunological association with the pathogenesis of BU.
In this review, we provide an overview of novel findings regarding the immunopathogenesis of BU.
American Psychological Association (APA)
Park, Un Chul& Kim, Tae Wan& Yu, Hyeong Gon. 2014. Immunopathogenesis of Ocular Behçet’s Disease. Journal of Immunology Research،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040936
Modern Language Association (MLA)
Park, Un Chul…[et al.]. Immunopathogenesis of Ocular Behçet’s Disease. Journal of Immunology Research No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-1040936
American Medical Association (AMA)
Park, Un Chul& Kim, Tae Wan& Yu, Hyeong Gon. Immunopathogenesis of Ocular Behçet’s Disease. Journal of Immunology Research. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-1040936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1040936