Intercalation of AceclofenacSulfobutyl Ether-β-cyclodextrin Complex into Layered Double Hydroxides through SwellingRestoration Reaction and Its Controlled-Release Properties

Abstract EN

Aceclofenac (AC)/sulfobutyl ether-β-cyclodextrin (SBE-β-CD) inclusion complex intercalated layered double hydroxides (LDHs) composite were prepared by swelling/restoration method.

After swelling/restoration, the d-spacing of LDHs is expanded to 2.23 nm, which clearly demonstrates the successful intercalation of AC/SBE-β-CD into LDHs layer.

AC/SBE-β-CD inclusion complex in the interlayer has monolayer arrangement based on the d-spacing of LDHs and torus thickness of SBE-β-CD.

The AC release performances were also studied in buffer solutions with different pH values.

The results show AC/SBE-β-CD intercalated LDHs not only enhance the dissolution profile of AC but also exhibit a controlled-release process, which indicates that the AC/SBE-β-CD-LDHs have a potential application in drug delivery agent.