The Tissue Response and Degradation of Electrospun Poly(ε-caprolactone)‎Poly(trimethylene-carbonate)‎ Scaffold in Subcutaneous Space of Mice

Abstract EN

Due to the advantage of controllability on the mechanical property and the degradation rates, electrospun PCL/PTMC nanofibrous scaffold could be appropriate for vascular tissue engineering.

However, the tissue response and degradation of electrospun PCL/PTMC scaffold in vivo have never been evaluated in detail.

So, electrospun PCL/PTMC scaffolds with different blend ratios were prepared in this study.

Mice subcutaneous implantation showed that the continuous degradation of PCL/PTMC scaffolds induced a lasted macrophage-mediated foreign body reaction, which could be in favor of the tissue regeneration in graft.