Intrauterine Growth Restriction Increases TNFα and Activates the Unfolded Protein Response in Male Rat Pups
Joint Authors
Campbell, Michael S.
Riddle, Emily S.
Lang, Brook Y.
Bierer, Ryann
Wang, Yan
Bagley, Heidi N.
Joss-Moore, Lisa A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Intrauterine growth restriction (IUGR) programs adult disease, including obesity and insulin resistance.
Our group previously demonstrated that IUGR dysregulates adipose deposition in male, but not female, weanling rats.
Dysregulated adipose deposition is often accompanied by the release of proinflammatory signaling molecules, such as tumor necrosis factor alpha (TNFα).
TNFα contributes to adipocyte inflammation and impaired insulin signaling.
TNFα has also been implicated in the activation of the unfolded protein response (UPR), which impairs insulin signaling.
We hypothesized that, in male rat pups, IUGR would increase TNFα, TNFR1, and components of the UPR (Hspa5, ATF6, p-eIF2α, and Ddit3) prior to the onset of obesity.
We further hypothesized that impaired glucose tolerance would occur after the onset of adipose dysfunction in male IUGR rats.
To test this hypothesis, we used a well-characterized rat model of uteroplacental insufficiency-induced IUGR.
Our primary findings are that, in male rats, IUGR (1) increased circulating and adipose TNFα, (2) increased mRNA levels of UPR components as well as p-eIF2a, and (3) impaired glucose tolerance after observed TNFα increased and after UPR activation.
We speculate that programmed dysregulation of TNFα and UPR contributed to the development of glucose intolerance in male IUGR rats.
American Psychological Association (APA)
Riddle, Emily S.& Campbell, Michael S.& Lang, Brook Y.& Bierer, Ryann& Wang, Yan& Bagley, Heidi N.…[et al.]. 2014. Intrauterine Growth Restriction Increases TNFα and Activates the Unfolded Protein Response in Male Rat Pups. Journal of Obesity،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042392
Modern Language Association (MLA)
Riddle, Emily S.…[et al.]. Intrauterine Growth Restriction Increases TNFα and Activates the Unfolded Protein Response in Male Rat Pups. Journal of Obesity No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-1042392
American Medical Association (AMA)
Riddle, Emily S.& Campbell, Michael S.& Lang, Brook Y.& Bierer, Ryann& Wang, Yan& Bagley, Heidi N.…[et al.]. Intrauterine Growth Restriction Increases TNFα and Activates the Unfolded Protein Response in Male Rat Pups. Journal of Obesity. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-1042392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1042392