Kaposi’s Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis
Joint Authors
Fontana, Judith M.
Mygatt, Justin G.
Conant, Katelyn L.
Parsons, Chris H.
Kaleeba, Johnan A. R.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
KSHV is the etiologic agent for Kaposi’s sarcoma (KS), a neoplasm that manifests most aggressively as multifocal lesions on parts of human skin with a propensity for inflammatory reactivity.
However, mechanisms that control evolution of KS from a benign hyperplasia to the histologically complex cutaneous lesion remain unknown.
In this study, we found that KSHV induces proteomic and morphological changes in melanocytes and melanoma-derived cell lines, accompanied by deregulation of the endogenous anti-inflammatory responses anchored by the MC1-R/α-MSH signaling axis.
We also identified two skin-derived cell lines that displayed differences in ability to support long-term KSHV infection and mapped this dichotomy to differences in (a) NF-κB activation status, (b) processing and expression of KSHV latency-associated nuclear antigen isoforms putatively associated with the viral lytic cycle, and (c) susceptibility to virus-induced changes in expression of key anti-inflammatory response genes that antagonize NF-κB, including MC1-R, POMC, TRP-1, and xCT.
Viral subversion of molecules that control the balance between latency and lytic replication represents a novel correlate of KSHV pathogenesis and tropism in skin and underscores the potential benefit of harnessing the endogenous anti-inflammatory processes as a therapeutic option for attenuating cutaneous KS and other proinflammatory outcomes of KSHV infection in high-risk individuals.
American Psychological Association (APA)
Fontana, Judith M.& Mygatt, Justin G.& Conant, Katelyn L.& Parsons, Chris H.& Kaleeba, Johnan A. R.. 2014. Kaposi’s Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis. Journal of Skin Cancer،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1043015
Modern Language Association (MLA)
Fontana, Judith M.…[et al.]. Kaposi’s Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis. Journal of Skin Cancer No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-1043015
American Medical Association (AMA)
Fontana, Judith M.& Mygatt, Justin G.& Conant, Katelyn L.& Parsons, Chris H.& Kaleeba, Johnan A. R.. Kaposi’s Sarcoma-Associated Herpesvirus Subversion of the Anti-Inflammatory Response in Human Skin Cells Reveals Correlates of Latency and Disease Pathogenesis. Journal of Skin Cancer. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-1043015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043015