The Wntβ-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria
Joint Authors
Silva-García, Octavio
Valdez-Alarcón, Juan J.
Baizabal-Aguirre, Víctor M.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Innate immunity against pathogenic bacteria is critical to protect host cells from invasion and infection as well as to develop an appropriate adaptive immune response.
During bacterial infection, different signaling transduction pathways control the expression of a wide range of genes that orchestrate a number of molecular and cellular events to eliminate the invading microorganisms and regulate inflammation.
The inflammatory response must be tightly regulated because uncontrolled inflammation may lead to tissue injury.
Among the many signaling pathways activated, the canonical Wnt/β-catenin has been recently shown to play an important role in the expression of several inflammatory molecules during bacterial infections.
Our main goal in this review is to discuss the mechanism used by several pathogenic bacteria to modulate the inflammatory response through the Wnt/β-catenin signaling pathway.
We think that a deep insight into the role of Wnt/β-catenin signaling in the inflammation may open new venues for biotechnological approaches designed to control bacterial infectious diseases.
American Psychological Association (APA)
Silva-García, Octavio& Valdez-Alarcón, Juan J.& Baizabal-Aguirre, Víctor M.. 2014. The Wntβ-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043471
Modern Language Association (MLA)
Silva-García, Octavio…[et al.]. The Wntβ-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria. Mediators of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1043471
American Medical Association (AMA)
Silva-García, Octavio& Valdez-Alarcón, Juan J.& Baizabal-Aguirre, Víctor M.. The Wntβ-Catenin Signaling Pathway Controls the Inflammatory Response in Infections Caused by Pathogenic Bacteria. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1043471
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043471