Synergistic Effect of Vaginal Trauma and Ovariectomy in a Murine Model of Stress Urinary Incontinence: Upregulation of Urethral Nitric Oxide Synthases and Estrogen Receptors

Joint Authors

Chen, Huey-Yi
Chen, Wen-Chi
Lin, Yu-Ning
Chen, Yung-Hsiang

Source

Mediators of Inflammation

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-08-31

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Diseases

Abstract EN

The molecular mechanisms underlying stress urinary incontinence (SUI) are unclear.

We aimed to evaluate the molecular alterations in mice urethras following vaginal trauma and ovariectomy (OVX).

Twenty-four virgin female mice were equally distributed into four groups: noninstrumented control; vaginal distension (VD) group; OVX group; and VD + OVX group.

Changes in leak point pressures (LPPs), genital tract morphology, body weight gain, plasma 17β-estradiol level and expressions of neuronal nitric oxide synthase (nNOS), induced nitric oxide synthase (iNOS), and estrogen receptors (ERs—ERα and ERβ) were analyzed.

Three weeks after VD, the four groups differed significantly in genital size and body weight gain.

Compared with the control group, the plasma estradiol levels were significantly decreased in the OVX and VD + OVX groups, and LPPs were significantly decreased in all three groups.

nNOS, iNOS, and ERα expressions in the urethra were significantly increased in the VD and VD + OVX groups, whereas ERβ expression was significantly increased only in the VD + OVX group.

These results show that SUI following vaginal trauma and OVX involves urethral upregulations of nNOS, iNOS, and ERs, suggesting that NO- and ER-mediated signaling might play a role in the synergistic effect of birth trauma and OVX-related SUI pathogenesis.

American Psychological Association (APA)

Chen, Huey-Yi& Chen, Wen-Chi& Lin, Yu-Ning& Chen, Yung-Hsiang. 2014. Synergistic Effect of Vaginal Trauma and Ovariectomy in a Murine Model of Stress Urinary Incontinence: Upregulation of Urethral Nitric Oxide Synthases and Estrogen Receptors. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043474

Modern Language Association (MLA)

Chen, Huey-Yi…[et al.]. Synergistic Effect of Vaginal Trauma and Ovariectomy in a Murine Model of Stress Urinary Incontinence: Upregulation of Urethral Nitric Oxide Synthases and Estrogen Receptors. Mediators of Inflammation No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1043474

American Medical Association (AMA)

Chen, Huey-Yi& Chen, Wen-Chi& Lin, Yu-Ning& Chen, Yung-Hsiang. Synergistic Effect of Vaginal Trauma and Ovariectomy in a Murine Model of Stress Urinary Incontinence: Upregulation of Urethral Nitric Oxide Synthases and Estrogen Receptors. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1043474

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1043474