Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis
Joint Authors
Grygiel-Górniak, Bogna
Puszczewicz, Mariusz
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-09-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Systemic sclerosis (SSc) is an autoimmune connective tissue disorder of unknown etiology.
This disease is characterized by a large variety of clinical patterns, which include the fibrosis of skin and visceral organs causing a variety of clinical manifestations.
Genetic and environmental factors participate in the etiology of this disease; however, recently many studies underline the oxidative background influencing the course and complications of this disease.
Reactive oxygen species (ROS) synthesized in SSc can mediate extra- and intracellular oxidative processes affecting endothelial cells and fibroblasts.
The estimation of prooxidative markers in the pathogenesis of SSc can enable the identification of useful markers for disease activity and, thus, may help in planning appropriate therapy focusing on the fibrotic or vascular pattern.
Recently, many attempts have been made to find antioxidative molecules (nutritional and pharmacological) reducing the prooxidant state in a variety of cells—mainly in endothelium and proliferating fibroblasts.
This paper presents both the background of oxidative stress processes in systemic sclerosis mediated by different mechanisms and the evidence suggesting which of the dietary and pharmacological antioxidants can be used as therapeutic targets for this disease.
American Psychological Association (APA)
Grygiel-Górniak, Bogna& Puszczewicz, Mariusz. 2014. Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043530
Modern Language Association (MLA)
Grygiel-Górniak, Bogna& Puszczewicz, Mariusz. Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043530
American Medical Association (AMA)
Grygiel-Górniak, Bogna& Puszczewicz, Mariusz. Oxidative Damage and Antioxidative Therapy in Systemic Sclerosis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043530