The Effects of Florfenicol on the Values of Serum Tumor Necrosis Factor- α and Other Biochemical Markers in Lipopolysaccharide-Induced Endotoxemia in Brown Trout
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of the present study was to determine the effects of florfenicol on the expected changes in sTNF-α, damage markers of the liver and kidney, and the lipid metabolism parameters in endotoxemic brown trout.
Ninety-six brown trout were included in this study.
After six of the fish were reserved as the control group, the remaining 90 fish were divided equally into 3 groups as follows: LPS (2 mg/kg, IP), LPS (2 mg/kg, IP) + florfenicol (40 mg/kg, IM), and florfenicol (40 mg/kg, IM).
Blood samples were obtained from the tail of the fish at 1.5, 3, 6, 10, and 24 hours.
The levels of sTNF-α were determined by ELISA and biochemical markers were evaluated with an autoanalyzer.
A significant increase was observed in the values of sTNF-α in the LPS and LPS + florfenicol groups ( P < 0.05 ).
Significant increases were found in the kidney and liver damage determinants in the LPS and LPS + florfenicol groups ( P < 0.05 ).
Irregular changes in the lipid metabolism parameters were observed in all the subgroups.
In conclusion, florfenicol does not affect the increases of sTNF-α caused by LPS and does not prevent liver or kidney damage; at least, it can be said that florfenicol does not have any evident positive effects on the acute endotoxemia of fish.
American Psychological Association (APA)
Er, Ayse& Dik, Burak. 2014. The Effects of Florfenicol on the Values of Serum Tumor Necrosis Factor- α and Other Biochemical Markers in Lipopolysaccharide-Induced Endotoxemia in Brown Trout. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043571
Modern Language Association (MLA)
Er, Ayse& Dik, Burak. The Effects of Florfenicol on the Values of Serum Tumor Necrosis Factor- α and Other Biochemical Markers in Lipopolysaccharide-Induced Endotoxemia in Brown Trout. Mediators of Inflammation No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-1043571
American Medical Association (AMA)
Er, Ayse& Dik, Burak. The Effects of Florfenicol on the Values of Serum Tumor Necrosis Factor- α and Other Biochemical Markers in Lipopolysaccharide-Induced Endotoxemia in Brown Trout. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-1043571
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043571