GSK-3β Inhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis
Joint Authors
Dahmen, Uta
Zhang, Hui
Wang, Wenjie
Fang, Haoshu
Yang, Yan
Li, Xiaolan
He, Junli
Jiang, Xiaojing
Wang, Weipeng
Liu, Shenpei
Hu, Jifa
Dirsch, Olaf
Liu, Anding
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-11-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Liver dysfunction has been known to occur frequently in cases of sepsis.
Excessive inflammation and apoptosis are pathological features of acute liver failure.
Recent studies suggest that activation of glycogen synthase kinase- (GSK-) 3β is involved in inflammation and apoptosis.
We aimed to investigate the protective effects of GSK-3β inhibition on polymicrobial sepsis-induced liver injury and to explore the possible mechanisms.
Polymicrobial sepsis was induced by cecal ligation and puncture (CLP), and SB216763 was used to inhibit GSK-3β in C57BL/6 mice.
GSK-3β was activated following CLP.
Administration of SB216763 decreased mortality, ameliorated liver injury, and reduced hepatic apoptosis.
The inhibition of GSK-3β also reduced leukocyte infiltration and hepatic inflammatory cytokine expression and release.
Moreover, GSK-3β inhibition suppressed the transcriptional activity of nuclear factor-kappa B (NF-κB) but enhanced the transcriptional activity of cAMP response element binding protein (CREB) in the liver.
In in vitro studies, GSK-3β inhibition reduced inflammatory cytokine production via modulation of NF-κB and CREB signaling pathways in lipopolysaccharide-stimulated macrophages.
In conclusion, these findings suggest that GSK-3β blockade protects against CLP-induced liver via inhibition of inflammation by modulating NF-κB and CREB activity and suppression of hepatic apoptosis.
American Psychological Association (APA)
Zhang, Hui& Wang, Wenjie& Fang, Haoshu& Yang, Yan& Li, Xiaolan& He, Junli…[et al.]. 2014. GSK-3β Inhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043691
Modern Language Association (MLA)
Zhang, Hui…[et al.]. GSK-3β Inhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043691
American Medical Association (AMA)
Zhang, Hui& Wang, Wenjie& Fang, Haoshu& Yang, Yan& Li, Xiaolan& He, Junli…[et al.]. GSK-3β Inhibition Attenuates CLP-Induced Liver Injury by Reducing Inflammation and Hepatic Cell Apoptosis. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043691
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043691