Scropolioside B Inhibits IL-1β and Cytokines Expression through NF-κB and Inflammasome NLRP3 Pathways
Joint Authors
Zhu, Tiantian
Zhang, Liuqiang
Ling, Shuang
Duan, Ju
Qian, Fei
Li, Yiming
Xu, Jin-Wen
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chronic inflammation is associated with various chronic illnesses including immunity disorders, cancer, neurodegeneration, and vascular diseases.
Iridoids are compounds with anti-inflammatory properties.
However their anti-inflammatory mechanism remains unclear.
Here, we report that scropolioside B, isolated from a Tibetan medicine (Scrophularia dentata Royle ex Benth.), blocked expressions of TNF, IL-1, and IL-32 through NF-κB pathway.
Scropolioside B inhibited NF-κB activity in a dose-dependent manner with IC50 values of 1.02 μmol/L.
However, catalpol, similar to scropolioside B, was not effective in inhibiting NF-κB activity.
Interestingly, scropolioside B and catalpol decreased the expression of NLRP3 and cardiolipin synthetase at both the mRNA and protein level.
Our results showed that scropolioside B is superior in inhibiting the expression, maturation, and secretion of IL-1β compared to catalpol.
These observations provide further understanding of the anti-inflammatory effects of iridoids and highlight scropolioside B as a potential drug for the treatment of rheumatoid arthritis and atherosclerosis.
American Psychological Association (APA)
Zhu, Tiantian& Zhang, Liuqiang& Ling, Shuang& Duan, Ju& Qian, Fei& Li, Yiming…[et al.]. 2014. Scropolioside B Inhibits IL-1β and Cytokines Expression through NF-κB and Inflammasome NLRP3 Pathways. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043828
Modern Language Association (MLA)
Zhu, Tiantian…[et al.]. Scropolioside B Inhibits IL-1β and Cytokines Expression through NF-κB and Inflammasome NLRP3 Pathways. Mediators of Inflammation No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1043828
American Medical Association (AMA)
Zhu, Tiantian& Zhang, Liuqiang& Ling, Shuang& Duan, Ju& Qian, Fei& Li, Yiming…[et al.]. Scropolioside B Inhibits IL-1β and Cytokines Expression through NF-κB and Inflammasome NLRP3 Pathways. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1043828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043828