Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer
Joint Authors
Hofmanová, Jiřina
Straková, Nicol
Vaculová, Alena Hyršlová
Tylichová, Zuzana
Šafaříková, Barbora
Skender, Belma
Kozubík, Alois
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Intestinal homeostasis is precisely regulated by a number of endogenous regulatory molecules but significantly influenced by dietary compounds.
Malfunction of this system may result in chronic inflammation and cancer.
Dietary essential n-3 polyunsaturated fatty acids (PUFAs) and short-chain fatty acid butyrate produced from fibre display anti-inflammatory and anticancer activities.
Both compounds were shown to modulate the production and activities of TNF family cytokines.
Cytokines from the TNF family (TNF-α, TRAIL, and FasL) have potent inflammatory activities and can also regulate apoptosis, which plays an important role in cancer development.
The results of our own research showed enhancement of apoptosis in colon cancer cells by a combination of either docosahexaenoic acid (DHA) or butyrate with TNF family cytokines, especially by promotion of the mitochondrial apoptotic pathway and modulation of NFκB activity.
This review is focused mainly on the interaction of dietary PUFAs and butyrate with these cytokines during colon inflammation and cancer development.
We summarised recent knowledge about the cellular and molecular mechanisms involved in such effects and outcomes for intestinal cell behaviour and pathologies.
Finally, the possible application for the prevention and therapy of colon inflammation and cancer is also outlined.
American Psychological Association (APA)
Hofmanová, Jiřina& Straková, Nicol& Vaculová, Alena Hyršlová& Tylichová, Zuzana& Šafaříková, Barbora& Skender, Belma…[et al.]. 2014. Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1043846
Modern Language Association (MLA)
Hofmanová, Jiřina…[et al.]. Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer. Mediators of Inflammation No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-1043846
American Medical Association (AMA)
Hofmanová, Jiřina& Straková, Nicol& Vaculová, Alena Hyršlová& Tylichová, Zuzana& Šafaříková, Barbora& Skender, Belma…[et al.]. Interaction of Dietary Fatty Acids with Tumour Necrosis Factor Family Cytokines during Colon Inflammation and Cancer. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-1043846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043846