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Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner
Joint Authors
Streck, Emilio Luiz
de Souza, Cláudio T.
Lira, Fábio Santos
Caperuto, Erico Chagas
Oliveira, Nara R. C.
Marques, Scherolin O.
Luciano, Thais F.
Pauli, José R.
Moura, Leandro P.
Pieri, Bruno L. S.
Engelmann, Julia
Scaini, Gisele
Pinho, Ricardo A.
Ropelle, Eduardo R.
Silva, Adelino S. R.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The present study investigated the effects of running at 0.8 or 1.2 km/h on inflammatory proteins (i.e., protein levels of TNF-α, IL-1β, and NF-κB) and metabolic proteins (i.e., protein levels of SIRT-1 and PGC-1α, and AMPK phosphorylation) in quadriceps of rats.
Male Wistar rats at 3 (young) and 18 months (middle-aged rats) of age were divided into nonexercised (NE) and exercised at 0.8 or 1.2 km/h.
The rats were trained on treadmill, 50 min per day, 5 days per week, during 8 weeks.
Forty-eight hours after the last training session, muscles were removed, homogenized, and analyzed using biochemical and western blot techniques.
Our results showed that: (a) running at 0.8 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with NE rats; (b) these responses were lower for the inflammatory proteins and higher for the metabolic proteins in young rats compared with middle-aged rats; (c) running at 1.2 km/h decreased the inflammatory proteins and increased the metabolic proteins compared with 0.8 km/h; (d) these responses were similar between young and middle-aged rats when trained at 1.2 km.
In summary, the age-related increases in inflammatory proteins, and the age-related declines in metabolic proteins can be reversed and largely improved by treadmill training.
American Psychological Association (APA)
Oliveira, Nara R. C.& Marques, Scherolin O.& Luciano, Thais F.& Pauli, José R.& Moura, Leandro P.& Caperuto, Erico Chagas…[et al.]. 2014. Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner. Mediators of Inflammation،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043962
Modern Language Association (MLA)
Oliveira, Nara R. C.…[et al.]. Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner. Mediators of Inflammation No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1043962
American Medical Association (AMA)
Oliveira, Nara R. C.& Marques, Scherolin O.& Luciano, Thais F.& Pauli, José R.& Moura, Leandro P.& Caperuto, Erico Chagas…[et al.]. Treadmill Training Increases SIRT-1 and PGC-1α Protein Levels and AMPK Phosphorylation in Quadriceps of Middle-Aged Rats in an Intensity-Dependent Manner. Mediators of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1043962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1043962