Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?
Joint Authors
Persson, Torbjörn
Cedazo-Minguez, Angel
Popescu, Bogdan Ovidiu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is the most common form of dementia in the elderly, with increasing prevalence and no disease-modifying treatment available yet.
A remarkable amount of data supports the hypothesis that oxidative stress is an early and important pathogenic operator in AD.
However, all clinical studies conducted to date did not prove a clear beneficial effect of antioxidant treatment in AD patients.
In the current work, we review the current knowledge about oxidative stress in AD pathogeny and we suggest future paths that are worth to be explored in animal models and clinical studies, in order to get a better approach of oxidative imbalance in this inexorable neurodegenerative disease.
American Psychological Association (APA)
Persson, Torbjörn& Popescu, Bogdan Ovidiu& Cedazo-Minguez, Angel. 2014. Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047028
Modern Language Association (MLA)
Persson, Torbjörn…[et al.]. Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047028
American Medical Association (AMA)
Persson, Torbjörn& Popescu, Bogdan Ovidiu& Cedazo-Minguez, Angel. Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047028