Exercise Training Preserves Ischemic Preconditioning in Aged Rat Hearts by Restoring the Myocardial Polyamine Pool
Joint Authors
Wang, Weiwei
Zhang, Hao
Xue, Guo
Zhang, Li
Zhang, Weihua
Wang, Lina
Lu, Fanghao
Li, Hongzhu
Bai, Shuzhi
Lin, Yan
Lou, Yu
Xu, Changqing
Zhao, Yajun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-10-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Ischemic preconditioning (IPC) strongly protects against myocardial ischemia reperfusion (IR) injury.
However, IPC protection is ineffective in aged hearts.
Exercise training reduces the incidence of age-related cardiovascular disease and upregulates the ornithine decarboxylase (ODC)/polyamine pathway.
The aim of this study was to investigate whether exercise can reestablish IPC protection in aged hearts and whether IPC protection is linked to restoration of the cardiac polyamine pool.
Methods.
Rats aging 3 or 18 months perform treadmill exercises with or without gradient respectively for 6 weeks.
Isolated hearts and isolated cardiomyocytes were exposed to an IR and IPC protocol.
Results.
IPC induced an increase in myocardial polyamines by regulating ODC and spermidine/spermine acetyltransferase (SSAT) in young rat hearts, but IPC did not affect polyamine metabolism in aged hearts.
Exercise training inhibited the loss of preconditioning protection and restored the polyamine pool by activating ODC and inhibiting SSAT in aged hearts.
An ODC inhibitor, α-difluoromethylornithine, abolished the recovery of preconditioning protection mediated by exercise.
Moreover, polyamines improved age-associated mitochondrial dysfunction in vitro.
Conclusion.
Exercise appears to restore preconditioning protection in aged rat hearts, possibly due to an increase in intracellular polyamines and an improvement in mitochondrial function in response to a preconditioning stimulus.
American Psychological Association (APA)
Wang, Weiwei& Zhang, Hao& Xue, Guo& Zhang, Li& Zhang, Weihua& Wang, Lina…[et al.]. 2014. Exercise Training Preserves Ischemic Preconditioning in Aged Rat Hearts by Restoring the Myocardial Polyamine Pool. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047037
Modern Language Association (MLA)
Wang, Weiwei…[et al.]. Exercise Training Preserves Ischemic Preconditioning in Aged Rat Hearts by Restoring the Myocardial Polyamine Pool. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-14.
https://search.emarefa.net/detail/BIM-1047037
American Medical Association (AMA)
Wang, Weiwei& Zhang, Hao& Xue, Guo& Zhang, Li& Zhang, Weihua& Wang, Lina…[et al.]. Exercise Training Preserves Ischemic Preconditioning in Aged Rat Hearts by Restoring the Myocardial Polyamine Pool. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-1047037
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047037