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Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy
Joint Authors
Picone, Pasquale
Nuzzo, Domenico
Caruana, Luca
Scafidi, Valeria
Di Carlo, M.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Mitochondria are dynamic ATP-generating organelle which contribute to many cellular functions including bioenergetics processes, intracellular calcium regulation, alteration of reduction-oxidation potential of cells, free radical scavenging, and activation of caspase mediated cell death.
Mitochondrial functions can be negatively affected by amyloid β peptide (Aβ), an important component in Alzheimer’s disease (AD) pathogenesis, and Aβ can interact with mitochondria and cause mitochondrial dysfunction.
One of the most accepted hypotheses for AD onset implicates that mitochondrial dysfunction and oxidative stress are one of the primary events in the insurgence of the pathology.
Here, we examine structural and functional mitochondrial changes in presence of Aβ.
In particular we review data concerning Aβ import into mitochondrion and its involvement in mitochondrial oxidative stress, bioenergetics, biogenesis, trafficking, mitochondrial permeability transition pore (mPTP) formation, and mitochondrial protein interaction.
Moreover, the development of AD therapy targeting mitochondria is also discussed.
American Psychological Association (APA)
Picone, Pasquale& Nuzzo, Domenico& Caruana, Luca& Scafidi, Valeria& Di Carlo, M.. 2014. Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047125
Modern Language Association (MLA)
Picone, Pasquale…[et al.]. Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy. Oxidative Medicine and Cellular Longevity No. 2014 (Dec. 2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1047125
American Medical Association (AMA)
Picone, Pasquale& Nuzzo, Domenico& Caruana, Luca& Scafidi, Valeria& Di Carlo, M.. Mitochondrial Dysfunction: Different Routes to Alzheimer’s Disease Therapy. Oxidative Medicine and Cellular Longevity. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1047125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047125