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15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity
Joint Authors
Lu, Jie
Li, Jingjing
Wang, Junshan
Wang, Fan
Zhang, Huawei
Fan, Zhuoyi
Yang, Jing
Shen, Miao
Zheng, Yuanyuan
Cheng, Ping
Wang, Chengfen
Xia, Yujing
Zhou, Ying-Qun
Chen, Kan
Zhu, Rong
Zhang, Yan
Guo, Chuan-Yong
Weiqi, Dai
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) reduces inflammation and has been identified as an anti-inflammatory prostaglandin in numerous animal models.
In this study, we investigated both effects of 15d-PGJ2 and its protection mechanism in concanavalin A- (ConA-) induced autoimmune hepatitis in mice.
Materials and Methods.
In vivo, Balb/C mice were injected with ConA (25 mg/kg) to induce acute autoimmune hepatitis, and 15d-PGJ2 (10 μg or 25 μg) was administered 1 h before the ConA injection.
The histological grade, proinflammatory cytokine levels, and NF-κB and PPARγ activity were determined 6, 12, and 24 h after the ConA injection.
In vitro, LO2 cells and RAW264.7 cells were pretreated with 15d-PGJ2 (2 μM) 1 h before the stimulation with ConA (30 μg/mL).
The NF-κB and PPARγ activity were determined 30 min after the ConA administration.
Results.
Pretreatment with 15d-PGJ2 reduced the pathological effects of ConA-induced autoimmune hepatitis and significantly reduced the levels of cytokines after injection.
15d-PGJ2 activated PPARγ, blocked the degradation of IκBα, and inhibited the translocation of NF-κB into the nucleus.
Conclusion.
These results indicate that 15d-PGJ2 protects against ConA-induced autoimmune hepatitis by reducing proinflammatory cytokines.
This reduction in inflammation may correlate with the activation of PPARγ and the reduction in NF-κB activity.
American Psychological Association (APA)
Chen, Kan& Li, Jingjing& Wang, Junshan& Xia, Yujing& Weiqi, Dai& Wang, Fan…[et al.]. 2014. 15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity. PPAR Research،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047269
Modern Language Association (MLA)
Chen, Kan…[et al.]. 15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity. PPAR Research No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1047269
American Medical Association (AMA)
Chen, Kan& Li, Jingjing& Wang, Junshan& Xia, Yujing& Weiqi, Dai& Wang, Fan…[et al.]. 15-Deoxy-γ12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPARγ and Reduction in NF-κB Activity. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1047269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047269