Decrease of PPAR δ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury
Joint Authors
Chen, Sheng-Hsien
Tsai, Cheng-Chia
Liu, Keng-Fan
Chen, Li-Jen
Cheng, Juei-Tang
Lee, Kung Shing
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Changes in the peroxisome proliferator-activated receptors-δ (PPARδ) expression in rats after spinal cord injury (SCI) have been previously reported.
Diabetic animals show a higher mortality after SCI.
However, the relationship between the progress of diabetes and PPARδ in SCI remains unknown.
In the present study, we used compressive SCI in streptozotocin-(STZ-) induced diabetic rats.
GW0742, a PPARδ agonist, was used to evaluate its merit in STZ rats after SCI.
Changes in PPARδ expression were detected by Western blot.
Survival rates were also estimated.
A lower expression of PPARδ in spinal cords of STZ-diabetic rats was observed.
In addition, the survival times in two-week induction diabetes were longer than those in eight-week induction group, which is consistent with the expression of PPARδ in the spinal cord.
Moreover, GW0742 significantly increased the survival time of STZ rats.
Furthermore, their motor function and pain response were attenuated by GSK0660, a selective PPARδ antagonist, but were enhanced by GW0742.
In conclusion, the data suggest that higher mortality rate in STZ-diabetic rats with SCI is associated with the decrease of PPARδ expression.
Thus, change of PPARδ expression with the progress of diabetes seems responsible for the higher mortality rate after SCI.
American Psychological Association (APA)
Tsai, Cheng-Chia& Lee, Kung Shing& Chen, Sheng-Hsien& Chen, Li-Jen& Liu, Keng-Fan& Cheng, Juei-Tang. 2014. Decrease of PPAR δ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury. PPAR Research،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047276
Modern Language Association (MLA)
Tsai, Cheng-Chia…[et al.]. Decrease of PPAR δ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury. PPAR Research No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047276
American Medical Association (AMA)
Tsai, Cheng-Chia& Lee, Kung Shing& Chen, Sheng-Hsien& Chen, Li-Jen& Liu, Keng-Fan& Cheng, Juei-Tang. Decrease of PPAR δ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord Injury. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047276
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047276