The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population
Joint Authors
Zhang, Liangqing
Ma, Guoda
Fu, Jiawu
Tao, Hua
Cui, Lili
Li, Keshen
Shao, Yiming
Li, Jia
Xie, Yuliu
Li, You
Wang, Haiyang
Mo, Guixi
Liu, Xin
Zhao, Bin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-binding nuclear receptor, and its activation plays a prominent role in regulating the inflammatory response.
Therefore, PPAR-γ has been suggested as a candidate gene for sepsis.
In the present study, we investigated the association between the Pro12Ala polymorphism of PPAR-γ and sepsis in a Han Chinese population.
A total of 308 patients with sepsis and 345 healthy controls were enrolled in this study.
Genotyping was performed using the polymerase chain reaction-ligation detection reaction (PCR-LDR) method.
No significant differences were detected in the allele and genotype distributions of the PPAR-γ Pro12Ala SNP between septic patients and controls ( P = 0.622 for genotype; P = 0.629 for allele).
However, stratification by subtypes (sepsis, septic shock, and severe sepsis) revealed a statistically significant difference in the frequency of the Ala allele and Ala-carrier genotype between the patients with the sepsis subtype and the healthy controls ( P = 0.014 for allele and P = 0.012 , for genotype).
Moreover, significant differences were found in the frequency of the Ala allele and genotype between the sepsis survivors and nonsurvivors (all P = 0.002 ).
In the survivors, the PPAR-γ Pro12Ala genotype was significantly associated with decreased disease severity and recovery time (all P < 0.001 ).
Thus, genetic polymorphism is thought to play a role in the development and outcome of sepsis.
American Psychological Association (APA)
Ma, Guoda& Wang, Haiyang& Mo, Guixi& Cui, Lili& Li, You& Shao, Yiming…[et al.]. 2014. The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population. PPAR Research،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047288
Modern Language Association (MLA)
Ma, Guoda…[et al.]. The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population. PPAR Research No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047288
American Medical Association (AMA)
Ma, Guoda& Wang, Haiyang& Mo, Guixi& Cui, Lili& Li, You& Shao, Yiming…[et al.]. The Pro12Ala Polymorphism of PPAR-γ Gene Is Associated with Sepsis Disease Severity and Outcome in Chinese Han Population. PPAR Research. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047288
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047288