Strategies Affording Prevascularized Cell-Based Constructs for Myocardial Tissue Engineering
Joint Authors
Govoni, Marco
Muscari, Claudio
Giordano, Emanuele
Bonafè, Francesca
Guarnieri, Carlo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-05
Country of Publication
Egypt
No. of Pages
8
Abstract EN
The production of a functional cardiac tissue to be transplanted in the injured area of the infarcted myocardium represents a challenge for regenerative medicine.
Most cell-based grafts are unviable because of inadequate perfusion; therefore, prevascularization might be a suitable approach for myocardial tissue engineering.
To this aim, cells with a differentiation potential towards vascular and cardiac muscle phenotypes have been cocultured in 2D or 3D appropriate scaffolds.
In addition to these basic approaches, more sophisticated strategies have been followed employing mixed-cell sheets, microvascular modules, and inosculation from vascular explants.
Technologies exerting spatial control of vascular cells, such as topographical surface roughening and ordered patterning, represent other ways to drive scaffold vascularization.
Finally, microfluidic devices and bioreactors exerting mechanical stress have also been employed for high-throughput scaling-up production in order to accelerate muscle differentiation and speeding the endothelialization process.
Future research should address issues such as how to optimize cells, biomaterials, and biochemical components to improve the vascular integration of the construct within the cardiac wall, satisfying the metabolic and functional needs of the myocardial tissue.
American Psychological Association (APA)
Muscari, Claudio& Giordano, Emanuele& Bonafè, Francesca& Govoni, Marco& Guarnieri, Carlo. 2014. Strategies Affording Prevascularized Cell-Based Constructs for Myocardial Tissue Engineering. Stem Cells International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047516
Modern Language Association (MLA)
Muscari, Claudio…[et al.]. Strategies Affording Prevascularized Cell-Based Constructs for Myocardial Tissue Engineering. Stem Cells International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1047516
American Medical Association (AMA)
Muscari, Claudio& Giordano, Emanuele& Bonafè, Francesca& Govoni, Marco& Guarnieri, Carlo. Strategies Affording Prevascularized Cell-Based Constructs for Myocardial Tissue Engineering. Stem Cells International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1047516
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047516