The Efficacy of Mesenchymal Stem Cell Transplantation in Caustic Esophagus Injury: An Experimental Study
Joint Authors
Kantarcioglu, Murat
Caliskan, Bahadir
Demirci, Hakan
Karacalioglu, Ozgur
Kekilli, Murat
Polat, Zulfikar
Gunal, Armagan
Akinci, Melih
Uysal, Cagri
Eksert, Sami
Gurel, Hasan
Celebi, Gurkan
Avcu, Ferit
Ural, Ali Ugur
Bagci, Sait
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Introduction.
Ingestion of corrosive substances may lead to stricture formation in esophagus as a late complication.
Full thickness injury seems to exterminate tissue stem cells of esophagus.
Mesenchymal stem cells (MSCs) can differentiate into specific cell lineages and have the capacity of homing in sites of injury.
Aim and Methods.
We aimed to investigate the efficacy of MSC transplantation, on prevention of esophageal damage and stricture formation after caustic esophagus injury in rats.
54 rats were allocated into four groups; 4 rats were sacrificed for MSC production.
Group 1, untreated controls (n: 10).
Group 2, membrane labeled MSCs-treated rats (n: 20).
Group 3, biodistribution of fluorodeoxyglucose labeled MSCs via positron emission tomography (PET) imaging (n: 10).
Group 4, sham operated (n: 10).
Standard caustic esophageal burns were created and MSCs were transplanted 24 hours after.
All rats were sacrificed at the 21st days.
Results.
PET scan images revealed the homing behavior of MSCs to the injury site.
The histopathology damage score was not significantly different from controls.
However, we demonstrated Dil labeled epithelial and muscle cells which were originating from transplanted MSCs.
Conclusion.
MSC transplantation after caustic esophageal injury may be a helpful treatment modality; however, probably repeated infusions are needed.
American Psychological Association (APA)
Kantarcioglu, Murat& Caliskan, Bahadir& Demirci, Hakan& Karacalioglu, Ozgur& Kekilli, Murat& Polat, Zulfikar…[et al.]. 2014. The Efficacy of Mesenchymal Stem Cell Transplantation in Caustic Esophagus Injury: An Experimental Study. Stem Cells International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047539
Modern Language Association (MLA)
Kantarcioglu, Murat…[et al.]. The Efficacy of Mesenchymal Stem Cell Transplantation in Caustic Esophagus Injury: An Experimental Study. Stem Cells International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1047539
American Medical Association (AMA)
Kantarcioglu, Murat& Caliskan, Bahadir& Demirci, Hakan& Karacalioglu, Ozgur& Kekilli, Murat& Polat, Zulfikar…[et al.]. The Efficacy of Mesenchymal Stem Cell Transplantation in Caustic Esophagus Injury: An Experimental Study. Stem Cells International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1047539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1047539