Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications
Joint Authors
Mehrbod, Parvaneh
Bin Mokhtar, Mazlin
Rahman, Heshu Sulaiman
Khoramnia, Anahita
Abd Ghani, Maaruf
Khan Ayob, Mohd
Bayat, Saadi
Abbasiliasi, Sahar
Ajdari, Daniel
Ariff, Arbakariya B.
Ajdari, Zahra
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Hypercholesterolemia is one of the most common chronic diseases in human.
Along with chemical therapy traditional medication is used as hypocholesterolemic remedy, however, with unfavorable side effects.
Recently, Monascus fermented product (MFP) has become a popular hypocholesterolemic natural supplement.
In the present study, the hypocholesterolemic activity of Monascus purpureus FTC5391 fermented product ethanolic extract (MFPe) was investigated in hypercholesterolemic rats.
Results showed that MFPe not only reduced the serum total cholesterol (TC), LDL-C, TG concentration, and TC/HDL-C ratio but also increased the HDL-C.
Further, solid phase extraction (SPE) was carried out to obtain the hypocholesterolemic bioactive fraction.
The high polar fraction of SPE increased the HDL-C (42%) and decreased the TC (53.3%), LDL-C (47%), and TG (50.7%) levels as well as TC/HDL-C ratio (69.1%) in serum.
The GC-MS results of the active fraction revealed two main compounds, isosorbide and erythritol, which act as coronary vasodilator compounds.
American Psychological Association (APA)
Ajdari, Zahra& Abd Ghani, Maaruf& Khan Ayob, Mohd& Bayat, Saadi& Bin Mokhtar, Mazlin& Abbasiliasi, Sahar…[et al.]. 2014. Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1048914
Modern Language Association (MLA)
Ajdari, Zahra…[et al.]. Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications. The Scientific World Journal No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-1048914
American Medical Association (AMA)
Ajdari, Zahra& Abd Ghani, Maaruf& Khan Ayob, Mohd& Bayat, Saadi& Bin Mokhtar, Mazlin& Abbasiliasi, Sahar…[et al.]. Hypocholesterolemic Activity of Monascus Fermented Product in the Absence of Monacolins with Partial Purification for Functional Food Applications. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-1048914
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1048914