Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria
Joint Authors
Abdul Wahab, Norhanom
Abd Malek, Sri Nurestri
Looi, Chung Yeng
Ahmed Hamdi, Omer Abdalla
Thomas, Noel Francis
Awang, Khalijah
Syed Abdul Rahman, Syarifah Nur
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-10
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Curcuma zedoaria also known as Temu putih is traditionally used in food preparations and treatment of various ailments including cancer.
The cytotoxic activity of hexane, dichloromethane, ethyl acetate, methanol, and the methanol-soxhlet extracts of Curcuma zedoaria rhizomes was tested on two human cancer cell lines (Ca Ski and MCF-7) and a noncancer cell line (HUVEC) using MTT assay.
Investigation on the chemical components in the hexane and dichloromethane fractions gave 19 compounds, namely, labda-8(17),12 diene-15,16 dial (1), dehydrocurdione (2), curcumenone (3), comosone II (4), curcumenol (5), procurcumenol (6), germacrone (7), zerumbone epoxide (8), zederone (9), 9-isopropylidene-2,6-dimethyl-11-oxatricyclo[6.2.1.01,5]undec-6-en-8-ol (10), furanodiene (11), germacrone-4,5-epoxide (12), calcaratarin A (13), isoprocurcumenol (14), germacrone-1,10-epoxide (15), zerumin A (16), curcumanolide A (17), curcuzedoalide (18), and gweicurculactone (19).
Compounds (1–19) were evaluated for their antiproliferative effect using MTT assay against four cancer cell lines (Ca Ski, MCF-7, PC-3, and HT-29).
Curcumenone (3) and curcumenol (5) displayed strong antiproliferative activity ( IC 50 = 8.3 ± 1.0 and 9.3 ± 0.3 μg/mL, resp.) and were found to induce apoptotic cell death on MCF-7 cells using phase contrast and Hoechst 33342/PI double-staining assay.
Thus, the present study provides basis for the ethnomedical application of Curcuma zedoaria in the treatment of breast cancer.
American Psychological Association (APA)
Ahmed Hamdi, Omer Abdalla& Syed Abdul Rahman, Syarifah Nur& Awang, Khalijah& Abdul Wahab, Norhanom& Looi, Chung Yeng& Thomas, Noel Francis…[et al.]. 2014. Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1049218
Modern Language Association (MLA)
Ahmed Hamdi, Omer Abdalla…[et al.]. Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria. The Scientific World Journal No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-1049218
American Medical Association (AMA)
Ahmed Hamdi, Omer Abdalla& Syed Abdul Rahman, Syarifah Nur& Awang, Khalijah& Abdul Wahab, Norhanom& Looi, Chung Yeng& Thomas, Noel Francis…[et al.]. Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-1049218
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1049218