An Efficient Sonochemical Synthesis of Novel Schiff’s Bases, Thiazolidine, and Pyrazolidine Incorporating 1,8-Naphthyridine Moiety and Their Cytotoxic Activity against HePG2 Cell Lines
Joint Authors
Ahmed, N. S.
AlFooty, K. O.
Khalifah, S. S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Novel Schiff’s bases 4a–e, 5a, 5b, and 6, thiazolidine 7a–d, and pyrazolidine 8 have been synthesized using the versatile synthon 4-hydroxy-2,7-dimethyl-1,8-naphthyridine 1.
Reactions carried out under ultrasound irradiation showed higher rates and yields than those done under silent conditions.
The newly synthesized compounds were evaluated for HepG2 cell growth inhibition.
The results obtained revealed that the tested compounds possess inhibitory effect on the growth of HepG2 liver cancer cells.
The results were compared to doxorubicin as a reference drug (IC50: 0.04).
Compounds 4a and 7b showed the highest inhibition activity against the HepG2 cell line (IC50: 0.047 and 0.041 µM, resp.) among all the tested compounds.
American Psychological Association (APA)
Ahmed, N. S.& AlFooty, K. O.& Khalifah, S. S.. 2014. An Efficient Sonochemical Synthesis of Novel Schiff’s Bases, Thiazolidine, and Pyrazolidine Incorporating 1,8-Naphthyridine Moiety and Their Cytotoxic Activity against HePG2 Cell Lines. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1050219
Modern Language Association (MLA)
Ahmed, N. S.…[et al.]. An Efficient Sonochemical Synthesis of Novel Schiff’s Bases, Thiazolidine, and Pyrazolidine Incorporating 1,8-Naphthyridine Moiety and Their Cytotoxic Activity against HePG2 Cell Lines. The Scientific World Journal No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-1050219
American Medical Association (AMA)
Ahmed, N. S.& AlFooty, K. O.& Khalifah, S. S.. An Efficient Sonochemical Synthesis of Novel Schiff’s Bases, Thiazolidine, and Pyrazolidine Incorporating 1,8-Naphthyridine Moiety and Their Cytotoxic Activity against HePG2 Cell Lines. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-1050219
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050219