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Influence of Estrogen Receptor α Polymorphisms on Bone Density in Response to Habitual Exercise in Japanese Postmenopausal Women
Joint Authors
Kondo, Hiroyo
Fujino, Hidemi
Nagatomo, Fumiko
Ishihara, Akihiko
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Estrogen receptor α (ERα) is one of candidate genes for osteoporosis.
This study examined the influence of ERα gene, PvuII, and XbaI genotypes on bone density of calcaneus in response to habitual exercise.
ERα polymorphisms were detected using PvuII and XbaI restriction enzymes in 316 Japanese postmenopausal women.
The bone density was significantly lower in the women carrying PP, pp, or xx genotype without habitual exercise than in the age-matched women without those genotypes.
The women carrying Pp genotype without habitual exercise had normal bone density compared to those without Pp genotype.
The women carrying PPxx or ppxx polymorphism without habitual exercise had low bone density compared to those with habitual exercise.
Thus, the reduction of bone density was attenuated in the women carrying PPxx or ppxx with habitual exercise.
In addition, habitual exercise was highly effective for the bone density in the women carrying xx homozygote.
These findings indicate that analyses of XbaI and PvuII polymorphisms of ERα may be useful to predict the effect of exercise on bone density, and habitual exercise attenuates the reduction of bone density in women with some genotypes.
American Psychological Association (APA)
Kondo, Hiroyo& Fujino, Hidemi& Nagatomo, Fumiko& Ishihara, Akihiko. 2014. Influence of Estrogen Receptor α Polymorphisms on Bone Density in Response to Habitual Exercise in Japanese Postmenopausal Women. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1050253
Modern Language Association (MLA)
Kondo, Hiroyo…[et al.]. Influence of Estrogen Receptor α Polymorphisms on Bone Density in Response to Habitual Exercise in Japanese Postmenopausal Women. The Scientific World Journal No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-1050253
American Medical Association (AMA)
Kondo, Hiroyo& Fujino, Hidemi& Nagatomo, Fumiko& Ishihara, Akihiko. Influence of Estrogen Receptor α Polymorphisms on Bone Density in Response to Habitual Exercise in Japanese Postmenopausal Women. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-1050253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050253