Duration of Antimicrobial Therapy in Community Acquired Pneumonia: Less Is More
Joint Authors
Abbo, Lilian
Cacopardo, Bruno
Pinzone, Marilia Rita
Nunnari, Giuseppe
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Community acquired pneumonia (CAP) represents the most common cause of infection-related morbidity and mortality worldwide.
Appropriate treatment of CAP is challenging and sometimes limited by the availability to obtain rapid and timely identification of the etiologic agent in order to initiate or deescalate the correct antimicrobial therapy.
As a consequence, prescribers frequently select empiric antimicrobial therapy using clinical judgment, local patterns of antimicrobial resistance, and, sometimes, individual patient expectations.
These issues may contribute to prolonged courses of inappropriate therapy.
In this review, we discuss the evidence and recommendations from international guidelines for the management of CAP and the clinical trials that specifically addressed duration of antimicrobial therapy for CAP in adults.
In randomized controlled trials comparing the clinical efficacy of a short-course antimicrobial regimen versus an extended-course regimen, no differences in terms of clinical success, bacterial eradication, adverse events, and mortality were observed.
The use of biomarkers, such as procalcitonin, to guide the initiation and duration of antimicrobial therapy may reduce total antibiotic exposure and treatment duration, healthcare costs, and the risk of developing antimicrobial resistance.
In clinical practice, antimicrobial stewardship interventions may improve the management of CAP and may help in reducing treatment duration.
Sometimes “less is more” in CAP.
American Psychological Association (APA)
Pinzone, Marilia Rita& Cacopardo, Bruno& Abbo, Lilian& Nunnari, Giuseppe. 2014. Duration of Antimicrobial Therapy in Community Acquired Pneumonia: Less Is More. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050944
Modern Language Association (MLA)
Pinzone, Marilia Rita…[et al.]. Duration of Antimicrobial Therapy in Community Acquired Pneumonia: Less Is More. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1050944
American Medical Association (AMA)
Pinzone, Marilia Rita& Cacopardo, Bruno& Abbo, Lilian& Nunnari, Giuseppe. Duration of Antimicrobial Therapy in Community Acquired Pneumonia: Less Is More. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1050944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1050944