Glycogen Synthase Kinase-3 Regulates Production of Amyloid-β Peptides and Tau Phosphorylation in Diabetic Rat Brain
Joint Authors
Qu, Zhong-Sen
Li, Liang
Sun, Xiao-Jiang
Zhao, Yu-Wu
Zhang, Jin
Geng, Zhi
Fu, Jian-Liang
Ren, Qing-Guo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The pathogenesis of diabetic neurological complications is not fully understood.
Diabetes mellitus (DM) and Alzheimer’s disease (AD) are characterized by amyloid deposits.
Glycogen synthase kinase-3 (GSK-3) plays an important role in the pathogenesis of AD and DM.
Here we tried to investigate the production of amyloid-β peptides (Aβ) and phosphorylation of microtubule-associated protein tau in DM rats and elucidate the role of GSK-3 and Akt (protein kinase B, PKB) in these processes.
Streptozotocin injection-induced DM rats displayed an increased GSK-3 activity, decreased activity and expression of Akt.
And Aβ40 and Aβ42 were found overproduced and the microtubule-associated protein tau was hyperphosphorylated in the hippocampus.
Furthermore, selective inhibition of GSK-3 by lithium could attenuate the conditions of Aβ overproduction and tau hyperphosphorylation.
Taken together, our studies suggest that GSK-3 regulates both the production of Aβ and the phosphorylation of tau in rat brain and may therefore contribute to DM caused AD-like neurological defects.
American Psychological Association (APA)
Qu, Zhong-Sen& Li, Liang& Sun, Xiao-Jiang& Zhao, Yu-Wu& Zhang, Jin& Geng, Zhi…[et al.]. 2014. Glycogen Synthase Kinase-3 Regulates Production of Amyloid-β Peptides and Tau Phosphorylation in Diabetic Rat Brain. The Scientific World Journal،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1051453
Modern Language Association (MLA)
Qu, Zhong-Sen…[et al.]. Glycogen Synthase Kinase-3 Regulates Production of Amyloid-β Peptides and Tau Phosphorylation in Diabetic Rat Brain. The Scientific World Journal No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-1051453
American Medical Association (AMA)
Qu, Zhong-Sen& Li, Liang& Sun, Xiao-Jiang& Zhao, Yu-Wu& Zhang, Jin& Geng, Zhi…[et al.]. Glycogen Synthase Kinase-3 Regulates Production of Amyloid-β Peptides and Tau Phosphorylation in Diabetic Rat Brain. The Scientific World Journal. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-1051453
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1051453