Molecular Backgrounds of ERAP1 Downregulation in Cervical Carcinoma
Joint Authors
Mehta, Akash M.
Osse, Michelle
Kolkman-Uljee, Sandra
Fleuren, Gert Jan
Jordanova, Ekaterina S.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-04
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The antigen processing machinery (APM) plays an important role in immune recognition of virally infected and transformed cells.
Defective expression of the APM component ERAP1 is associated with progression and poor clinical outcome in cervical carcinoma.
However, the underlying mechanisms of ERAP1 protein downregulation remain to be established.
We investigated ERAP1 mRNA expression levels in 14 patients with established ERAP1 protein downregulation.
To further examine the possible pretranscriptional mechanisms of ERAP1 downregulation, ERAP1 DNA mutation status was analyzed alongside existing data on various single nucleotide polymorphisms.
Moreover, loss of heterozygosity at various loci in the ERAP1 gene was investigated.
In cases with ERAP1 protein downregulation, ERAP1 mRNA quantities were found to be significantly lower than in a cohort with normal ERAP1 protein expression P = 0.001 .
Loss of heterozygosity was demonstrated to occur in up to 50% of tumors with ERAP1 downregulation.
Our data indicate that ERAP1 downregulation is associated with loss of heterozygosity.
These data provide the first insight into in vivo mechanisms of ERAP1 downregulation in cervical carcinoma.
American Psychological Association (APA)
Mehta, Akash M.& Osse, Michelle& Kolkman-Uljee, Sandra& Fleuren, Gert Jan& Jordanova, Ekaterina S.. 2015. Molecular Backgrounds of ERAP1 Downregulation in Cervical Carcinoma. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1052352
Modern Language Association (MLA)
Mehta, Akash M.…[et al.]. Molecular Backgrounds of ERAP1 Downregulation in Cervical Carcinoma. Analytical Cellular Pathology No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1052352
American Medical Association (AMA)
Mehta, Akash M.& Osse, Michelle& Kolkman-Uljee, Sandra& Fleuren, Gert Jan& Jordanova, Ekaterina S.. Molecular Backgrounds of ERAP1 Downregulation in Cervical Carcinoma. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1052352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052352