PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women
Joint Authors
Gbelcová, H.
Bakeš, P.
Priščáková, P.
Šišovský, V.
Hojsíková, I.
Straka, Ľ.
Konečný, M.
Markus, J.
D’Acunto, C. W.
Ruml, T.
Böhmer, D.
Danihel, Ľ.
Repiská, V.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Phosphatase and tensin homolog (PTEN) is a protein that acts as a tumor suppressor by dephosphorylating the lipid second messenger phosphatidylinositol 3,4,5-trisphosphate.
Loss of PTEN function has been implicated in the pathogenesis of a number of different tumors, particularly endometrial carcinoma (ECa).
ECa is the most common neoplasia of the female genital tract.
Our study evaluates an association between the morphological appearance of endometrial hyperplasia and endometrial carcinoma and the degree of PTEN alterations.
A total of 45 endometrial biopsies from Slovak women were included in present study.
Formalin-fixed and paraffin-embedded tissue samples with simple hyperplasia (3), complex hyperplasia (5), atypical complex hyperplasia (7), endometrioid carcinomas G1 (20) and G3 (5), and serous carcinoma (5) were evaluated for the presence of mutations in coding regions of PTEN gene, the most frequently mutated tumor suppressor gene in endometrial carcinoma.
75% of the detected mutations were clustered in exons 5 and 8.
Out of the 39 mutations detected in 24 cases, 20 were frameshifts and 19 were nonsense, missense, or silent mutations.
Some specimens harboured more than one mutation.
The results of current study on Slovak women were compared to a previous study performed on Polish population.
The two sets of results were similar.
American Psychological Association (APA)
Gbelcová, H.& Bakeš, P.& Priščáková, P.& Šišovský, V.& Hojsíková, I.& Straka, Ľ.…[et al.]. 2015. PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052368
Modern Language Association (MLA)
Gbelcová, H.…[et al.]. PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women. Analytical Cellular Pathology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1052368
American Medical Association (AMA)
Gbelcová, H.& Bakeš, P.& Priščáková, P.& Šišovský, V.& Hojsíková, I.& Straka, Ľ.…[et al.]. PTEN Sequence Analysis in Endometrial Hyperplasia and Endometrial Carcinoma in Slovak Women. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052368