MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models
Joint Authors
Fioruci-Fontanelli, Beatriz Aparecida
Chuffa, Luiz Gustavo A.
Mendes, Leonardo O.
Pinheiro, Patricia Fernanda F.
Delella, Flávia Karina
Kurokawa, Cilmery S.
Felisbino, Sérgio Luis
Martinez, Francisco Eduardo
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We investigated whether chronic ethanol intake is capable of altering the MMP-2 and MMP-9 activities and TIMP-2 and TIMP-1 expression in the dorsal and lateral prostatic lobes of low (UChA) and high (UChB) ethanol-preferring rats.
MMP-2 and MMP-9 activities and TIMP-1 and TIMP-2 expression were significantly reduced in the lateral prostatic lobe of the ethanol drinking animals.
Dorsal prostatic lobe was less affected showing no significant alterations in these proteins, except for a reduction in the TIMP-1 expression in UChA rats.
These important findings demonstrate that chronic ethanol intake impairs the physiological balance of the prostate extracellular matrix turnover, through downregulation of MMPs, which may contribute to the development of prostatic diseases.
Furthermore, since these proteins are also components of prostate secretion, the negative impact of chronic ethanol intake on fertility may also involve reduction of MMPs and TIMPs in the seminal fluid.
American Psychological Association (APA)
Fioruci-Fontanelli, Beatriz Aparecida& Chuffa, Luiz Gustavo A.& Mendes, Leonardo O.& Pinheiro, Patricia Fernanda F.& Delella, Flávia Karina& Kurokawa, Cilmery S.…[et al.]. 2015. MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models. Analytical Cellular Pathology،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052376
Modern Language Association (MLA)
Fioruci-Fontanelli, Beatriz Aparecida…[et al.]. MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models. Analytical Cellular Pathology No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1052376
American Medical Association (AMA)
Fioruci-Fontanelli, Beatriz Aparecida& Chuffa, Luiz Gustavo A.& Mendes, Leonardo O.& Pinheiro, Patricia Fernanda F.& Delella, Flávia Karina& Kurokawa, Cilmery S.…[et al.]. MMP-2 and MMP-9 Activities and TIMP-1 and TIMP-2 Expression in the Prostatic Tissue of Two Ethanol-Preferring Rat Models. Analytical Cellular Pathology. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1052376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052376