Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis
Joint Authors
Ala, Yaswanth
Pasha, Mohammed Khalid
Rao, Raja Narasimha
Komaravalli, Prasanna Latha
Jahan, Parveen
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-09-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Objectives.
Cytokines regulate immune response and inflammation and play a crucial role in depigmentation process of vitiligo.
The present study aimed to estimate the serum levels of pro- and anti-inflammatory cytokines, IFN-γ and IL-10, and their ratios in nonsegmental vitiligo patients and healthy individuals from India.
Methods.
Blood samples were collected from 280 subjects and serum IFN-γ and IL-10 levels were measured using standard ELISA.
Results.
Nonsegmental vitiligo patients showed increased levels of IFN-γ ( 12.4 ± 3.2 versus 9.9 ± 4.4 pg/mL) and decreased levels of IL-10 ( 9.3 ± 1.7 versus 11.5 ± 5 pg/mL) compared to controls.
Ratio of IFN-γ : IL-10 differed significantly from patients to controls ( p < 0.05 ).
IFN-γ concentrations and IFN-γ : IL-10 ratio varied significantly with respect to clinical variants, disease stability, and social habits (smoking and alcohol consumption) and showed a positive correlation with disease duration.
Family history of vitiligo was significantly associated with IFN-γ : IL-10 ratio but not with their individual levels.
Conclusion.
The ratio of IFN-γ : IL-10 serum levels may be considered as one of the promising immunological markers in nonsegmental vitiligo.
This is the first study considering multiple aspects in relation to ratio of cytokine levels.
Similar studies with large samples are warranted to confirm our observations.
American Psychological Association (APA)
Ala, Yaswanth& Pasha, Mohammed Khalid& Rao, Raja Narasimha& Komaravalli, Prasanna Latha& Jahan, Parveen. 2015. Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis. Autoimmune Diseases،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052386
Modern Language Association (MLA)
Ala, Yaswanth…[et al.]. Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis. Autoimmune Diseases No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1052386
American Medical Association (AMA)
Ala, Yaswanth& Pasha, Mohammed Khalid& Rao, Raja Narasimha& Komaravalli, Prasanna Latha& Jahan, Parveen. Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis. Autoimmune Diseases. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1052386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1052386