Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months
Joint Authors
Asiimwe-Kateera, Brenda
Veldhuijzen, Nienke
Balinda, Jean Paul
Rusine, John
Eagle, Sally
Vyankandondera, Joseph
Mugabekazi, Julie
Boer, Kimberly
Asiimwe, Anita
Reiss, Peter
van de Wijgert, Janneke
Lange, J. M. A.
Ondoa, Pascale
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Adult women (n=113) and men (n=100) initiating combination antiretroviral therapy (cART) and women not yet eligible for cART (n=199) in Kigali, Rwanda, were followed for 6–24 months between 2007 and 2010.
In the cART groups, 21% of patients required a drug change due to side effects and 11% of patients had virological failure (defined as >1,000 HIV RNA copies/mL) after 12 months of cART.
About a third of the pregnancies since HIV diagnosis were unintended.
The proportion of women in the pre-cART group using modern contraception other than condoms (50%) was similar to women in the general population, but this proportion was only 25% in women initiating cART.
Of the women who carried at least one pregnancy to term since having been diagnosed HIV-positive, a third reported to have participated in a prevention-of-mother-to-child-transmission (PMTCT, option A) intervention.
Many patients were coinfected with herpes simplex virus type 2 (79–92%), human papillomavirus (38–53%), and bacterial sexually transmitted infections (STIs) with no differences between groups.
We applaud the Rwandan government for having strengthened family planning and PMTCT services and for having introduced HPV vaccination in recent years, but additional work is needed to strengthen STI and HPV-related cancer screening and management in the HIV-positive population.
American Psychological Association (APA)
Asiimwe-Kateera, Brenda& Veldhuijzen, Nienke& Balinda, Jean Paul& Rusine, John& Eagle, Sally& Vyankandondera, Joseph…[et al.]. 2015. Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months. AIDS Research and Treatment،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1053968
Modern Language Association (MLA)
Asiimwe-Kateera, Brenda…[et al.]. Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months. AIDS Research and Treatment No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1053968
American Medical Association (AMA)
Asiimwe-Kateera, Brenda& Veldhuijzen, Nienke& Balinda, Jean Paul& Rusine, John& Eagle, Sally& Vyankandondera, Joseph…[et al.]. Combination Antiretroviral Therapy for HIV in Rwandan Adults: Clinical Outcomes and Impact on Reproductive Health up to 24 Months. AIDS Research and Treatment. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1053968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1053968