Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth
Joint Authors
Prat, Annik
Declercq, Jeroen
Brouwers, Bas
Pruniau, Vincent P. E. G.
Stijnen, Pieter
Tuand, Krizia
Meulemans, Sandra
Seidah, Nabil G.
Khatib, Abdel-Majid
Creemers, John W. M.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Proprotein convertases are subtilisin-like serine endoproteases that cleave and hence activate a variety of proproteins, including growth factors, receptors, metalloproteases, and extracellular matrix proteins.
Therefore, it has been suggested that inhibition of the ubiquitously expressed proprotein convertase FURIN might be a good therapeutic strategy for several tumor types.
Whether this is also the case for hepatocellular carcinoma (HCC) is currently not clear.
In a mouse model for HCC expression of Furin was not altered in the tumors, while those of PC7, PC5/6, and PACE4 significantly decreased, at least at some time points.
To investigate the impact of Furin inhibition on the development and progression of HCC in this model, Furin was genetically ablated in the liver.
Furin inactivation resulted in an increased tumor mass after 5 weeks.
This was not caused by decreased apoptosis, since no differences in the apoptosis index could be observed.
However, it could at least partially be explained by increased hepatocyte proliferation at 5 weeks.
The tumors of the Furin knockout mice were histologically similar to those in wild type mice.
In conclusion, liver-specific Furin inhibition in HCC enhances the tumor formation and will not be a good therapeutic strategy for this tumor type.
American Psychological Association (APA)
Declercq, Jeroen& Brouwers, Bas& Pruniau, Vincent P. E. G.& Stijnen, Pieter& Tuand, Krizia& Meulemans, Sandra…[et al.]. 2015. Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054369
Modern Language Association (MLA)
Declercq, Jeroen…[et al.]. Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054369
American Medical Association (AMA)
Declercq, Jeroen& Brouwers, Bas& Pruniau, Vincent P. E. G.& Stijnen, Pieter& Tuand, Krizia& Meulemans, Sandra…[et al.]. Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054369
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054369