![](/images/graphics-bg.png)
Could α-Synuclein Amyloid-Like Aggregates Trigger a Prionic Neuronal Invasion?
Joint Authors
Busquets, Maria Antònia
Espargaró, Alba
Estelrich, Joan
Sabate, Raimon
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-03-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Parkinson’s disease (PD), a progressive neurodegenerative disease primarily affecting voluntary and controlled movement, is characterized by abnormal accumulations of α-synuclein (α-syn) in intraneuronal Lewy bodies.
In the last years, the increased number of evidences from both the in vitro and in vivo studies has shown the ability of α-syn to misfold in amyloid conformations and to spread via neuron-to-neuron transmission, suggesting a prion-like behaviour.
However, in contrast to prion protein (PrP), α-syn transmission is far from neuronal invasion.
The high neuronal toxicity of both mature fibres and oligomeric species, as well as the intracellular localization of the protein and the difficulty to be secreted, could be key factors impeding the prion ability of α-syn aggregates.
American Psychological Association (APA)
Busquets, Maria Antònia& Espargaró, Alba& Estelrich, Joan& Sabate, Raimon. 2015. Could α-Synuclein Amyloid-Like Aggregates Trigger a Prionic Neuronal Invasion?. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054486
Modern Language Association (MLA)
Busquets, Maria Antònia…[et al.]. Could α-Synuclein Amyloid-Like Aggregates Trigger a Prionic Neuronal Invasion?. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054486
American Medical Association (AMA)
Busquets, Maria Antònia& Espargaró, Alba& Estelrich, Joan& Sabate, Raimon. Could α-Synuclein Amyloid-Like Aggregates Trigger a Prionic Neuronal Invasion?. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054486