AlginatePoly(γ-glutamic Acid) Base Biocompatible Gel for Bone Tissue Engineering
Joint Authors
Kuo, Y.-L.
Chan, Wing P.
Kung, Fu-Chen
Lai, Wen-Fu Thomas
Yang, Ming-Chien
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A technique for synthesizing biocompatible hydrogels by cross-linking calcium-form poly(γ-glutamic acid), alginate sodium, and Pluronic F-127 was created, in which alginate can be cross-linked by Ca2+ from Ca–γ-PGA directly and γ-PGA molecules introduced into the alginate matrix to provide pH sensitivity and hemostasis.
Mechanical properties, swelling behavior, and blood compatibility were investigated for each hydrogel compared with alginate and for γ-PGA hydrogel with the sodium form only.
Adding F-127 improves mechanical properties efficiently and influences the temperature-sensitive swelling of the hydrogels but also has a minor effect on pH-sensitive swelling and promotes anticoagulation.
MG-63 cells were used to test biocompatibility.
Gelation occurred gradually through change in the elastic modulus as the release of calcium ions increased over time and caused ionic cross-linking, which promotes the elasticity of gel.
In addition, the growth of MG-63 cells in the gel reflected nontoxicity.
These results showed that this biocompatible scaffold has potential for application in bone materials.
American Psychological Association (APA)
Chan, Wing P.& Kung, Fu-Chen& Kuo, Y.-L.& Yang, Ming-Chien& Lai, Wen-Fu Thomas. 2015. AlginatePoly(γ-glutamic Acid) Base Biocompatible Gel for Bone Tissue Engineering. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054546
Modern Language Association (MLA)
Chan, Wing P.…[et al.]. AlginatePoly(γ-glutamic Acid) Base Biocompatible Gel for Bone Tissue Engineering. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054546
American Medical Association (AMA)
Chan, Wing P.& Kung, Fu-Chen& Kuo, Y.-L.& Yang, Ming-Chien& Lai, Wen-Fu Thomas. AlginatePoly(γ-glutamic Acid) Base Biocompatible Gel for Bone Tissue Engineering. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054546