Oligoclonal Bands in Cerebrospinal Fluid of Black Patients with Multiple Sclerosis
Joint Authors
Callegaro, Dagoberto
Gama, Paulo Diniz da
Machado, Luís dos Ramos
Livramento, José Antonio
Gomes, Hélio Rodrigues
Adoni, Tarso
Morales, Rogério de Rizo
Gama, Rodrigo Assad Diniz da
Gama, Daniel Assad Diniz da
Lana-Peixoto, Marco Aurélio
Fragoso, Yara Dadalti
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Genetic susceptibility is a well-recognized factor in the onset of multiple sclerosis (MS).
The objective of this study was to determine the frequency of oligoclonal bands (OCB) restricted to the cerebrospinal fluid, in an ethnically mixed group of MS patients in the city of São Paulo, Brazil.
Techniques used to detect OCB consisted of isoelectric focusing followed by immunoblotting.
OCB were found in 49 (54.4%) out of 90 patients with clinically definite MS; out of the 23 brown/black patients, 17 (73.9%) were OCB+; out of the 66 white patients, 32 (48.5%) were OCB+; and the only patient yellow was OCB+ (p=0.05).
Analysis of the IgG index was also consistent with the findings, but with lower statistical significance.
The data presented in our study show that the ethnic differences in MS extend to the immune response.
American Psychological Association (APA)
Gama, Paulo Diniz da& Machado, Luís dos Ramos& Livramento, José Antonio& Gomes, Hélio Rodrigues& Adoni, Tarso& Morales, Rogério de Rizo…[et al.]. 2015. Oligoclonal Bands in Cerebrospinal Fluid of Black Patients with Multiple Sclerosis. BioMed Research International،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1054669
Modern Language Association (MLA)
Gama, Paulo Diniz da…[et al.]. Oligoclonal Bands in Cerebrospinal Fluid of Black Patients with Multiple Sclerosis. BioMed Research International No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1054669
American Medical Association (AMA)
Gama, Paulo Diniz da& Machado, Luís dos Ramos& Livramento, José Antonio& Gomes, Hélio Rodrigues& Adoni, Tarso& Morales, Rogério de Rizo…[et al.]. Oligoclonal Bands in Cerebrospinal Fluid of Black Patients with Multiple Sclerosis. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1054669
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054669