Emerging Threats for Human Health in Poland: Pathogenic Isolates from Drug Resistant Acanthamoeba Keratitis Monitored in terms of Their In Vitro Dynamics and Temperature Adaptability
Joint Authors
Szaflik, Jacek P.
Chomicz, Lidia
Padzik, Marcin
Zawadzki, Paweł J.
Pawłowski, Witold
Dybicz, Monika
Conn, D. Bruce
Walochnik, Julia
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Amphizoic amoebae generate a serious human health threat due to their pathogenic potential as facultative parasites, causative agents of vision-threatening Acanthamoeba keratitis (AK).
Recently, AK incidences have been reported with increasing frequency worldwide, particularly in contact lens wearers.
In our study, severe cases of AK in Poland and respective pathogenic isolates were assessed at clinical, morphological, and molecular levels.
Misdiagnoses and the unsuccessful treatment in other ophthalmic units delayed suitable therapy, and resistance to applied chemicals resulted in severe courses and treatment difficulties.
Molecular assessment indicated that all sequenced pathogenic corneal isolates deriving from Polish patients with AK examined by us showed 98–100% homology with Acanthamoeba genotype T4, the most prevalent genotype in this human ocular infection worldwide.
In vitro assays revealed that the pathogenic strains are able to grow at elevated temperature and have a wide adaptive capability.
This study is our subsequent in vitro investigation on pathogenic Acanthamoeba strains of AK originating from Polish patients.
Further investigations designed to foster a better understanding of the factors leading to an increase of AK observed in the past years in Poland may help to prevent or at least better cope with future cases.
American Psychological Association (APA)
Chomicz, Lidia& Conn, D. Bruce& Padzik, Marcin& Szaflik, Jacek P.& Walochnik, Julia& Zawadzki, Paweł J.…[et al.]. 2015. Emerging Threats for Human Health in Poland: Pathogenic Isolates from Drug Resistant Acanthamoeba Keratitis Monitored in terms of Their In Vitro Dynamics and Temperature Adaptability. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054677
Modern Language Association (MLA)
Chomicz, Lidia…[et al.]. Emerging Threats for Human Health in Poland: Pathogenic Isolates from Drug Resistant Acanthamoeba Keratitis Monitored in terms of Their In Vitro Dynamics and Temperature Adaptability. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1054677
American Medical Association (AMA)
Chomicz, Lidia& Conn, D. Bruce& Padzik, Marcin& Szaflik, Jacek P.& Walochnik, Julia& Zawadzki, Paweł J.…[et al.]. Emerging Threats for Human Health in Poland: Pathogenic Isolates from Drug Resistant Acanthamoeba Keratitis Monitored in terms of Their In Vitro Dynamics and Temperature Adaptability. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1054677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054677