Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model
Joint Authors
Hirahara, Ichiro
Kusano, Eiji
Imai, Toshimi
Morishita, Yoshiyuki
Muto, Shigeaki
Sato, Hideki
Onishi, Akira
Nagata, Daisuke
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-05-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Peritoneal dialysis (PD) is a common treatment for patients with reduced or absent renal function.
Long-term PD leads to peritoneal injury with structural changes and functional decline.
At worst, peritoneal injury leads to encapsulating peritoneal sclerosis (EPS), which is a serious complication of PD.
In order to carry out PD safely, it is important to define the mechanism of progression of peritoneal injury and EPS.
We prepared rat models of peritoneal injury by intraperitoneal administration of glucose degradation products, such as methylglyoxal (MGO) or formaldehyde (FA), chlorhexidine gluconate (CG), and talc.
In rats treated with MGO, peritoneal fibrous thickening with the appearance of basophilic spindle cells with podoplanin, cytokeratin, and α-smooth muscle actin at the surface of the peritoneum was observed.
These cells may have been derived from mesothelial cells by epithelial-to-mesenchymal transition.
In FA- or CG-treated rats, the peritoneum was thickened, and mesothelial cells were absent at the surface of the peritoneum.
The CG- or MGO-treated rats presented with a so-called abdominal cocoon.
In the talc-treated rats, extensive peritoneal adhesion and peritoneal thickening were observed.
MGO-induced peritoneal injury model may reflect human histopathology and be suitable to analyze the mechanism of progression of peritoneal injury and EPS.
American Psychological Association (APA)
Hirahara, Ichiro& Sato, Hideki& Imai, Toshimi& Onishi, Akira& Morishita, Yoshiyuki& Muto, Shigeaki…[et al.]. 2015. Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model. BioMed Research International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054906
Modern Language Association (MLA)
Hirahara, Ichiro…[et al.]. Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model. BioMed Research International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1054906
American Medical Association (AMA)
Hirahara, Ichiro& Sato, Hideki& Imai, Toshimi& Onishi, Akira& Morishita, Yoshiyuki& Muto, Shigeaki…[et al.]. Methylglyoxal Induced Basophilic Spindle Cells with Podoplanin at the Surface of Peritoneum in Rat Peritoneal Dialysis Model. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1054906
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1054906