A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress
Joint Authors
Kapuy, Orsolya
Bánhegyi, Gábor
Holczer, Marianna
Márton, Margita
Kurucz, Anita
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-04-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
One of the most important tasks of a living organism is to maintain its genetic integrity with respect to stress.
Endoplasmic reticulum (ER) has a crucial role in sensing cellular homeostasis by controlling metabolism, proteostasis, and several signaling processes.
ER stressors can induce autophagy-dependent survival; however excessive level of stress results in apoptotic cell death.
Although many molecular components of these networks have already been discovered, the analysis of the dynamical features of the regulatory network of life-or-death decision is still lacking.
Our goal was to incorporate both theoretical and molecular biological techniques to explore the autophagy-apoptosis crosstalk under ER stress.
Using various levels of different ER stressors we confirmed that the control network always generated an evidently detectable autophagy-dependent threshold for apoptosis activation.
We explored the features of this threshold by introducing both autophagy activators and inhibitors, and transient treatment with excessive level of ER stressor was also performed.
Our experimental data were also supported by a stochastic approach.
Our analysis suggests that even if the switch-like characteristic of apoptosis activation is hardly seen on population level the double negative feedback loop between autophagy and apoptosis inducers introduces bistability in the control network.
American Psychological Association (APA)
Holczer, Marianna& Márton, Margita& Kurucz, Anita& Bánhegyi, Gábor& Kapuy, Orsolya. 2015. A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055046
Modern Language Association (MLA)
Holczer, Marianna…[et al.]. A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1055046
American Medical Association (AMA)
Holczer, Marianna& Márton, Margita& Kurucz, Anita& Bánhegyi, Gábor& Kapuy, Orsolya. A Comprehensive Systems Biological Study of Autophagy-Apoptosis Crosstalk during Endoplasmic Reticulum Stress. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1055046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055046