Polymorphisms of NFκB1 and IκBα and Their Synergistic Effect on Nasopharyngeal Carcinoma Susceptibility
Joint Authors
Liu, Yehua
Qiu, Fuman
Yang, Lei
Yang, Rongrong
Yang, Xiaorong
Huang, Dongsheng
Fang, Wenxiang
Zhang, Lisha
Jiang, Qingping
Zhang, Lan
Zhou, Yifeng
Lu, Jiachun
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Nasopharyngeal carcinoma (NPC) is a multifactoral and polygenic disease with high prevalence in Southeast Asia and Southern China.
Environmental factors and genetic susceptibility play important roles in NPC pathogenesis.
In the present study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) in nuclear factor-kappa B (NFκB) and its inhibitor (IκBα) conferred consistent risks for NPC.
Four putatively functional SNPs (NFκB1: rs28362491del>ins ATTG; NFκB2: rs12769316G>A; IκBα : rs2233406C>T and rs696G>A) were analyzed to evaluate their associations with NPC risk in total 1590 NPC cases and 1979 cancer-free controls.
We found that the rs28362491 insATTG variants (ins/del + ins/ins) in NFκB1 conferred an increased risk of NPC (odds ratio [ OR ] = 1.30 , 95% confidence interval [ CI ] = 1.09 –1.55, and P = 2.80 × 10 - 3 ) compared with the del/del homozygous genotype.
The rs696AA variant in IκBα had an increased risk of NPC ( OR = 1 .
41 , 95% CI = 1.20 –1.66, and P = 2.28 × 10 - 5 ) by decreasing IκBα expression due to the modulation of microRNA hsa-miR-449a.
Furthermore, both adverse genotypes of NFκB/IκBα and their interaction also exerted an increased risk on NPC.
Taken together, Our findings indicated that genetic variants in NFκB1 (rs28362491del>ins ATTG) and IκBα (rs696G>A) and their synergistic effect might contribute to NPC predisposition.
American Psychological Association (APA)
Liu, Yehua& Qiu, Fuman& Yang, Lei& Yang, Rongrong& Yang, Xiaorong& Huang, Dongsheng…[et al.]. 2015. Polymorphisms of NFκB1 and IκBα and Their Synergistic Effect on Nasopharyngeal Carcinoma Susceptibility. BioMed Research International،Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055193
Modern Language Association (MLA)
Liu, Yehua…[et al.]. Polymorphisms of NFκB1 and IκBα and Their Synergistic Effect on Nasopharyngeal Carcinoma Susceptibility. BioMed Research International No. 2015 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1055193
American Medical Association (AMA)
Liu, Yehua& Qiu, Fuman& Yang, Lei& Yang, Rongrong& Yang, Xiaorong& Huang, Dongsheng…[et al.]. Polymorphisms of NFκB1 and IκBα and Their Synergistic Effect on Nasopharyngeal Carcinoma Susceptibility. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-9.
https://search.emarefa.net/detail/BIM-1055193
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055193