Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells
Joint Authors
Florencio-Silva, Rinaldo
Sasso-Cerri, Estela
Simões, Manuel Jesus
Sasso, G. R. S.
Cerri, Paulo Sérgio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-13
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Bone tissue is continuously remodeled through the concerted actions of bone cells, which include bone resorption by osteoclasts and bone formation by osteoblasts, whereas osteocytes act as mechanosensors and orchestrators of the bone remodeling process.
This process is under the control of local (e.g., growth factors and cytokines) and systemic (e.g., calcitonin and estrogens) factors that all together contribute for bone homeostasis.
An imbalance between bone resorption and formation can result in bone diseases including osteoporosis.
Recently, it has been recognized that, during bone remodeling, there are an intricate communication among bone cells.
For instance, the coupling from bone resorption to bone formation is achieved by interaction between osteoclasts and osteoblasts.
Moreover, osteocytes produce factors that influence osteoblast and osteoclast activities, whereas osteocyte apoptosis is followed by osteoclastic bone resorption.
The increasing knowledge about the structure and functions of bone cells contributed to a better understanding of bone biology.
It has been suggested that there is a complex communication between bone cells and other organs, indicating the dynamic nature of bone tissue.
In this review, we discuss the current data about the structure and functions of bone cells and the factors that influence bone remodeling.
American Psychological Association (APA)
Florencio-Silva, Rinaldo& Sasso, G. R. S.& Sasso-Cerri, Estela& Simões, Manuel Jesus& Cerri, Paulo Sérgio. 2015. Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells. BioMed Research International،Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1055432
Modern Language Association (MLA)
Florencio-Silva, Rinaldo…[et al.]. Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells. BioMed Research International No. 2015 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1055432
American Medical Association (AMA)
Florencio-Silva, Rinaldo& Sasso, G. R. S.& Sasso-Cerri, Estela& Simões, Manuel Jesus& Cerri, Paulo Sérgio. Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-17.
https://search.emarefa.net/detail/BIM-1055432
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055432