Improvement of BMI after Lifestyle Intervention Is Associated with Normalisation of Elevated ELF Score and Liver Stiffness in Obese Children
Joint Authors
Goldschmidt, Imeke
Di Nanni, André
Streckenbach, Carolin
Schnell, Kerstin
Danne, Thomas
Baumann, Ulrich
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Noninvasive tools to diagnose nonalcoholic fatty liver disease (NAFLD), including transient elastography (TE) and enhanced liver fibrosis panel (ELF), have only been evaluated in children with biopsy-proven NAFLD.
We evaluated the prevalence of ELF and TE abnormalities in obese children without clinical liver disease and examined the effects of BMI stabilization on ELF and TE in a longitudinal approach.
Methods.
39 obese children (17 m, age 12.3 (7.6–17.4) years) who participated in a 12-month lifestyle-intervention program underwent TE and ELF testing at baseline and at completion of the program.
Results were compared with data from a nonobese paediatric cohort.
Results.
TE and ELF at baseline were significantly elevated compared to controls (TE: 5.9 (3.4–8.3) kPa versus 4.45 (2.45–8.85) kPa, P < 0.01 ; ELF: 9.0 (7.87–9.60) versus 8.6 (7.33–11.52), P = 0.033 ).
All children with elevated TE and ELF results had normal transaminases.
After the program, ELF and TE normalized.
Reduction of ELF and TE was associated with a decrease in BMI centile.
Conclusion.
Abnormal TE and ELF results in obese children suggest presence of NAFLD even when transaminases are normal.
TE and ELF might be used as monitoring tools for NAFLD.
BMI stabilisation normalizes TE and ELF, underlining the impact of lifestyle intervention.
American Psychological Association (APA)
Goldschmidt, Imeke& Di Nanni, André& Streckenbach, Carolin& Schnell, Kerstin& Danne, Thomas& Baumann, Ulrich. 2015. Improvement of BMI after Lifestyle Intervention Is Associated with Normalisation of Elevated ELF Score and Liver Stiffness in Obese Children. BioMed Research International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055544
Modern Language Association (MLA)
Goldschmidt, Imeke…[et al.]. Improvement of BMI after Lifestyle Intervention Is Associated with Normalisation of Elevated ELF Score and Liver Stiffness in Obese Children. BioMed Research International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1055544
American Medical Association (AMA)
Goldschmidt, Imeke& Di Nanni, André& Streckenbach, Carolin& Schnell, Kerstin& Danne, Thomas& Baumann, Ulrich. Improvement of BMI after Lifestyle Intervention Is Associated with Normalisation of Elevated ELF Score and Liver Stiffness in Obese Children. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1055544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055544