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3,3′-Diindolylmethane: A Promising Sensitizer of γ-Irradiation
Joint Authors
Wang, Wenjing
Lv, Maomin
Huangfu, Chaoji
Wang, Fang
Zhang, Jingang
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Radiotherapy is an effective treatment modality in the clinical treatment of breast cancer.
The present work investigated the effect of 3,3′-diindolylmethane (DIM) on γ-irradiation sensitizing human breast carcinoma.
Methods.
Cell survival, intracellular ROS levels, cell cycle distribution, cell apoptosis, and expression of proteins related to apoptosis were measured with MTT assays, flow cytometry, and Western blot analysis, respectively.
Results.
In vitro DIM plus γ-irradiation arrested the activity of G2/M phase cell cycle, increased intracellular ROS level, significantly suppressed PARP (poly ADP-ribose polymerase), and enhanced γ-irradiation-induced apoptosis, thereby inhibiting the proliferation of MCF-7 cells.
Conclusion.
These data provide a rationale for the use of DIM as a promising sensitizer of γ-irradiation.
American Psychological Association (APA)
Wang, Wenjing& Lv, Maomin& Huangfu, Chaoji& Wang, Fang& Zhang, Jingang. 2015. 3,3′-Diindolylmethane: A Promising Sensitizer of γ-Irradiation. BioMed Research International،Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055580
Modern Language Association (MLA)
Wang, Wenjing…[et al.]. 3,3′-Diindolylmethane: A Promising Sensitizer of γ-Irradiation. BioMed Research International No. 2015 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1055580
American Medical Association (AMA)
Wang, Wenjing& Lv, Maomin& Huangfu, Chaoji& Wang, Fang& Zhang, Jingang. 3,3′-Diindolylmethane: A Promising Sensitizer of γ-Irradiation. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-6.
https://search.emarefa.net/detail/BIM-1055580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1055580