Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma
Joint Authors
Chen, Shiu-Nan
Wu, Yu-Sheng
Wang, Wan-Jhen
Chen, Sherwin
Liu, Chi-Feng
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-06-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The present study showed that oral mushroom beta-glucan treatment significantly increased IFN-γ mRNA expression but significantly reduced COX-2 mRNA expression within the lung.
For LLC tumor model, oral Ganoderma lucidum or Antrodia camphorata polysaccharides treatments significantly reduced TGF-β production in serum.
In addition, IL-12 and IFN-γ mRNA expression were significantly increased, but IL-6, IL-10, COX-2, and TGF-β mRNA expression were substantially following oral mushroom polysaccharides treatments.
The study highlights the efficacious effect of mushroom polysaccharides for ameliorating the immune suppression in the tumor microenvironment.
Increased M1 phenotype of tumor-associated macrophages and attenuated M2 phenotype of tumor-associated macrophages could be achieved by ingesting mushroom polysaccharides.
American Psychological Association (APA)
Wang, Wan-Jhen& Wu, Yu-Sheng& Chen, Sherwin& Liu, Chi-Feng& Chen, Shiu-Nan. 2015. Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma. BioMed Research International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056089
Modern Language Association (MLA)
Wang, Wan-Jhen…[et al.]. Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma. BioMed Research International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1056089
American Medical Association (AMA)
Wang, Wan-Jhen& Wu, Yu-Sheng& Chen, Sherwin& Liu, Chi-Feng& Chen, Shiu-Nan. Mushroom β-Glucan May Immunomodulate the Tumor-Associated Macrophages in the Lewis Lung Carcinoma. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1056089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056089