Insights into Neuroinflammation in Parkinson’s Disease: From Biomarkers to Anti-Inflammatory Based Therapies
Joint Authors
Rocha, Natália Pessoa
de Miranda, Aline Silva
Teixeira, Antonio Lucio
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-07-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Parkinson’s disease (PD) is the second most common neurodegenerative disorder worldwide, being characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta.
Among several putative factors that may contribute to PD pathogenesis, inflammatory mechanisms may play a pivotal role.
The involvement of microglial activation as well as of brain and peripheral immune mediators in PD pathophysiology has been reported by clinical and experimental studies.
These inflammatory biomarkers evaluated by imaging techniques and/or by biological sample analysis have become valuable tools for PD diagnosis and prognosis.
Regardless of the significant increase in the number of people suffering from PD, there are still no established disease-modifying or neuroprotective therapies for it.
There is growing evidence of protective effect of anti-inflammatory drugs on PD development.
Herein, we reviewed the current literature regarding the central nervous system and peripheral immune biomarkers in PD and advances in diagnostic and prognostic tools as well as the neuroprotective effects of anti-inflammatory therapies.
American Psychological Association (APA)
Rocha, Natália Pessoa& de Miranda, Aline Silva& Teixeira, Antonio Lucio. 2015. Insights into Neuroinflammation in Parkinson’s Disease: From Biomarkers to Anti-Inflammatory Based Therapies. BioMed Research International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056196
Modern Language Association (MLA)
Rocha, Natália Pessoa…[et al.]. Insights into Neuroinflammation in Parkinson’s Disease: From Biomarkers to Anti-Inflammatory Based Therapies. BioMed Research International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1056196
American Medical Association (AMA)
Rocha, Natália Pessoa& de Miranda, Aline Silva& Teixeira, Antonio Lucio. Insights into Neuroinflammation in Parkinson’s Disease: From Biomarkers to Anti-Inflammatory Based Therapies. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1056196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056196