Single-Fraction Radiotherapy for CD30+ Lymphoproliferative Disorders
Joint Authors
Gentile, Michelle S.
Martinez-Escala, Maria Estela
Thomas, Tarita O.
Guitart, Joan
Rosen, Steven
Kuzel, Timothy
Mittal, Bharat B.
Source
Issue
Vol. 2015, Issue 2015 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-10-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objectives.
CD30+ lymphoproliferative disorder is a rare variant of cutaneous T-cell lymphoma.
Sustained complete response following first-line treatments is rare.
This retrospective review evaluates the response of refractory or recurrent lesions to palliative radiation therapy.
Methods.
The records of 6 patients with 12 lesions, treated with radiation therapy, were reviewed.
All patients received previous first-line treatments.
Patients with clinical and pathological evidence of symptomatic CD30+ lymphoproliferative disorder, with no history of other cutaneous T-cell lymphoma variants, and with no prior radiation therapy to the index site were included.
Results.
The median age of patients was 50.5 years (range, 15–83 years).
Median size of the treated lesions was 2.5 cm (range, 2–7 cm).
Four sites were treated with a single fraction of 750–800 cGy (n=3) and 8 sites were treated with 4000–4500 cGy in 200–250 cGy fractions (n=3).
Radiation therapy was administered with electrons and bolus.
Median follow-up was 113 months (range, 16–147 months).
For all sites, there was 100% complete response with acute grade 1-2 dermatitis.
Conclusions.
For recurrent and symptomatic radiation-naïve CD30+ lymphoproliferative disorder lesions, palliative radiation therapy shows excellent response.
A single fraction of 750–800 cGy is as effective as a multifractionated course and more convenient.
American Psychological Association (APA)
Gentile, Michelle S.& Martinez-Escala, Maria Estela& Thomas, Tarita O.& Guitart, Joan& Rosen, Steven& Kuzel, Timothy…[et al.]. 2015. Single-Fraction Radiotherapy for CD30+ Lymphoproliferative Disorders. BioMed Research International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056201
Modern Language Association (MLA)
Gentile, Michelle S.…[et al.]. Single-Fraction Radiotherapy for CD30+ Lymphoproliferative Disorders. BioMed Research International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1056201
American Medical Association (AMA)
Gentile, Michelle S.& Martinez-Escala, Maria Estela& Thomas, Tarita O.& Guitart, Joan& Rosen, Steven& Kuzel, Timothy…[et al.]. Single-Fraction Radiotherapy for CD30+ Lymphoproliferative Disorders. BioMed Research International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1056201
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1056201